Prolactinoma as the first manifestation of Gardner's syndrome

Geoffrey S. Goodin, M. Beth McCarville, Stephen N. Thibodeau, Stephen X. Skapek, Joseph D. Khoury, Sheri L. Spunt

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Familial adenomatous polyposis (FAP) is an inherited condition causing numerous adenomatous colorectal polyps and a markedly elevated risk of colon cancer. FAP may be associated with various extracolonic manifestations such as desmoid fibromatosis and osteomas (termed Gardner's syndrome) and brain tumors, usually medulloblastoma or glioma [termed Brain Tumor Polyposis (BTP) syndrome type 2]. We describe a pediatric patient who initially presented with prolactinoma and later was found to have Gardner's syndrome. A germline mutation of the APC (adenomatous polyposis coli) gene was identified. Our case illustrates the association between prolactinoma and FAP, which may represent a rare subtype of Gardner's and BTP syndromes.

Original languageEnglish (US)
Pages (from-to)409-412
Number of pages4
JournalPediatric Blood and Cancer
Volume50
Issue number2
DOIs
StatePublished - Feb 1 2008

Keywords

  • Desmoid tumor
  • Familial adenomatous polyposis
  • Gardner's syndrome
  • Pituitary adenoma
  • Prolactinoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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  • Cite this

    Goodin, G. S., McCarville, M. B., Thibodeau, S. N., Skapek, S. X., Khoury, J. D., & Spunt, S. L. (2008). Prolactinoma as the first manifestation of Gardner's syndrome. Pediatric Blood and Cancer, 50(2), 409-412. https://doi.org/10.1002/pbc.20985