Prolonged survival in fetal rabbit surgery

Peter E.M. Butler, C. Derek Sims, Mark A. Randolph, Alexander P. Van De Water, W. P.Andrew Lee

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Timing and outcome of antenatal surgical intervention is being explored using fetal animal models. Models that are currently used range from larger animals with fewer offspring and higher cost to smaller animals with larger litters and lower cost. The rabbit is an ideal 'small' animal model for experimentation in the third trimester, with a large litter, short gestation and a relatively large fetus. This paper reports methods by which prolonged survival (greater than 110 days) may be achieved in as many as 60% of operated fetuses following complex fetal surgery in the rabbit.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalJournal of Investigative Surgery
Volume11
Issue number1
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Keywords

  • Fetal surgery
  • Prolonged survival
  • Rabbit

ASJC Scopus subject areas

  • Surgery

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  • Cite this

    Butler, P. E. M., Sims, C. D., Randolph, M. A., Van De Water, A. P., & Lee, W. P. A. (1998). Prolonged survival in fetal rabbit surgery. Journal of Investigative Surgery, 11(1), 57-61. https://doi.org/10.3109/08941939809032180