Abstract
Purpose To report the first clinical results and value assessment of prompt gamma imaging for in vivo proton range verification in pencil beam scanning mode. Methods and Materials A stand-alone, trolley-mounted, prototype prompt gamma camera utilizing a knife-edge slit collimator design was used to record the prompt gamma signal emitted along the proton tracks during delivery of proton therapy for a brain cancer patient. The recorded prompt gamma depth detection profiles of individual pencil beam spots were compared with the expected profiles simulated from the treatment plan. Results In 6 treatment fractions recorded over 3 weeks, the mean (± standard deviation) range shifts aggregated over all spots in 9 energy layers were −0.8 ± 1.3 mm for the lateral field, 1.7 ± 0.7 mm for the right-superior-oblique field, and −0.4 ± 0.9 mm for the vertex field. Conclusions This study demonstrates the feasibility and illustrates the distinctive benefits of prompt gamma imaging in pencil beam scanning treatment mode. Accuracy in range verification was found in this first clinical case to be better than the range uncertainty margin applied in the treatment plan. These first results lay the foundation for additional work toward tighter integration of the system for in vivo proton range verification and quantification of range uncertainties.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 210-218 |
| Number of pages | 9 |
| Journal | International Journal of Radiation Oncology Biology Physics |
| Volume | 99 |
| Issue number | 1 |
| DOIs | |
| State | Published - Sep 1 2017 |
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ASJC Scopus subject areas
- Radiation
- Oncology
- Radiology Nuclear Medicine and imaging
- Cancer Research
Cite this
Prompt Gamma Imaging for In Vivo Range Verification of Pencil Beam Scanning Proton Therapy. / Xie, Yunhe; Bentefour, El Hassane; Janssens, Guillaume; Smeets, Julien; Vander Stappen, François; Hotoiu, Lucian; Yin, Lingshu; Dolney, Derek; Avery, Stephen; O'Grady, Fionnbarr; Prieels, Damien; McDonough, James; Solberg, Timothy D.; Lustig, Robert A.; Lin, Alexander; Teo, Boon Keng K.
In: International Journal of Radiation Oncology Biology Physics, Vol. 99, No. 1, 01.09.2017, p. 210-218.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prompt Gamma Imaging for In Vivo Range Verification of Pencil Beam Scanning Proton Therapy
AU - Xie, Yunhe
AU - Bentefour, El Hassane
AU - Janssens, Guillaume
AU - Smeets, Julien
AU - Vander Stappen, François
AU - Hotoiu, Lucian
AU - Yin, Lingshu
AU - Dolney, Derek
AU - Avery, Stephen
AU - O'Grady, Fionnbarr
AU - Prieels, Damien
AU - McDonough, James
AU - Solberg, Timothy D.
AU - Lustig, Robert A.
AU - Lin, Alexander
AU - Teo, Boon Keng K.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Purpose To report the first clinical results and value assessment of prompt gamma imaging for in vivo proton range verification in pencil beam scanning mode. Methods and Materials A stand-alone, trolley-mounted, prototype prompt gamma camera utilizing a knife-edge slit collimator design was used to record the prompt gamma signal emitted along the proton tracks during delivery of proton therapy for a brain cancer patient. The recorded prompt gamma depth detection profiles of individual pencil beam spots were compared with the expected profiles simulated from the treatment plan. Results In 6 treatment fractions recorded over 3 weeks, the mean (± standard deviation) range shifts aggregated over all spots in 9 energy layers were −0.8 ± 1.3 mm for the lateral field, 1.7 ± 0.7 mm for the right-superior-oblique field, and −0.4 ± 0.9 mm for the vertex field. Conclusions This study demonstrates the feasibility and illustrates the distinctive benefits of prompt gamma imaging in pencil beam scanning treatment mode. Accuracy in range verification was found in this first clinical case to be better than the range uncertainty margin applied in the treatment plan. These first results lay the foundation for additional work toward tighter integration of the system for in vivo proton range verification and quantification of range uncertainties.
AB - Purpose To report the first clinical results and value assessment of prompt gamma imaging for in vivo proton range verification in pencil beam scanning mode. Methods and Materials A stand-alone, trolley-mounted, prototype prompt gamma camera utilizing a knife-edge slit collimator design was used to record the prompt gamma signal emitted along the proton tracks during delivery of proton therapy for a brain cancer patient. The recorded prompt gamma depth detection profiles of individual pencil beam spots were compared with the expected profiles simulated from the treatment plan. Results In 6 treatment fractions recorded over 3 weeks, the mean (± standard deviation) range shifts aggregated over all spots in 9 energy layers were −0.8 ± 1.3 mm for the lateral field, 1.7 ± 0.7 mm for the right-superior-oblique field, and −0.4 ± 0.9 mm for the vertex field. Conclusions This study demonstrates the feasibility and illustrates the distinctive benefits of prompt gamma imaging in pencil beam scanning treatment mode. Accuracy in range verification was found in this first clinical case to be better than the range uncertainty margin applied in the treatment plan. These first results lay the foundation for additional work toward tighter integration of the system for in vivo proton range verification and quantification of range uncertainties.
UR - http://www.scopus.com/inward/record.url?scp=85027732273&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027732273&partnerID=8YFLogxK
U2 - 10.1016/j.ijrobp.2017.04.027
DO - 10.1016/j.ijrobp.2017.04.027
M3 - Article
C2 - 28816148
AN - SCOPUS:85027732273
VL - 99
SP - 210
EP - 218
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
SN - 0360-3016
IS - 1
ER -