Prospective assessment after pediatric cardiac ablation

Recurrence at 1 year after initially successful ablation of supraventricular tachycardia

George F. Van Hare, Harold Javitz, Dorit Carmelli, J. Philip Saul, Ronn E. Tanel, Peter S. Fischbach, Ronald J. Kanter, Michael Schaffer, Ann Dunnigan, Steven Colan, Gerald Serwer, Macdonald Dick, Robert Campbell, Yung R. Lau, Edward P. Walsh, Timothy Knilans, William Scott, Jeanny Park, Peter Karpawich, Margaret Bell & 25 others Richard Friedman, Steven Weindling, Christopher Erickson, Ruchir Sehra, Kevin M. Shannon, Ming Lon Young, Frank Fish, Steven Fishberger, Bertrand Ross, John Kugler, Anne M. Dubin, Mary Sokoloski, Lee Beerman, Marc LeGras, Seshadri Balaji, Coburn Porter, Susan Etheridge, James C. Perry, Frank Cecchin, Frank Zimmerman, Burt Bromberg, Craig Byrum, Ricardo Samson, Robert Hamilton, Jeff Moak

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Objectives. A multicenter prospective study was performed to assess the results and risks associated with radiofrequency ablation in children. This report focuses on recurrences following initially successful ablation. Methods. Patients recruited for the study were aged 0 to 16 years and had supraventricular tachycardia due to accessory pathways or atrioventricular nodal reentrant tachycardia (AVNRT), excluding patients with more than trivial congenital heart disease. A total of 481 patients were recruited into the prospective cohort and were followed at 2, 6, and 12 months following ablation. Results. There were 517 successfully ablated substrates out of 540 attempted (95.7%). Loss to follow-up for individual substrates was 3.3%, 10.6%, and 21.2% at 2, 6, and 12 months, respectively. Recurrence was observed in 7.0%, 9.2%, and 10.7% of these substrates at 2, 6, and 12 months, respectively (adjusted for loss to follow-up as an independent source of data censoring). Recurrence rate varied by substrate location (24.6% for right septal, 15.8% for right free wall, 9.3% for left free wall, and 4.8% for left septal), as well as for AVNRT versus all others (4.8% vs 12.9%) at 12 months. The recurrence rate was higher for substrates ablated using power control but was not a function of whether isoproterenol was used for postablation testing. Conclusions. Recurrence after initially successful ablation occurs commonly in children. It is least common after AVNRT ablation and most common following ablation of right-sided pathways. These results serve as a benchmark for the time course of recurrence following initially successful ablation of supraventricular tachycardia in children.

Original languageEnglish (US)
Pages (from-to)188-196
Number of pages9
JournalHeart Rhythm
Volume1
Issue number2
DOIs
StatePublished - Jul 2004

Fingerprint

Supraventricular Tachycardia
Atrioventricular Nodal Reentry Tachycardia
Pediatrics
Recurrence
Benchmarking
Information Storage and Retrieval
Isoproterenol
Multicenter Studies
Heart Diseases
Prospective Studies

Keywords

  • Ablation
  • Atrioventricular nodal reentry
  • Children
  • Recurrence
  • Registry
  • Wolff-Parkinson-White syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Prospective assessment after pediatric cardiac ablation : Recurrence at 1 year after initially successful ablation of supraventricular tachycardia. / Van Hare, George F.; Javitz, Harold; Carmelli, Dorit; Saul, J. Philip; Tanel, Ronn E.; Fischbach, Peter S.; Kanter, Ronald J.; Schaffer, Michael; Dunnigan, Ann; Colan, Steven; Serwer, Gerald; Dick, Macdonald; Campbell, Robert; Lau, Yung R.; Walsh, Edward P.; Knilans, Timothy; Scott, William; Park, Jeanny; Karpawich, Peter; Bell, Margaret; Friedman, Richard; Weindling, Steven; Erickson, Christopher; Sehra, Ruchir; Shannon, Kevin M.; Young, Ming Lon; Fish, Frank; Fishberger, Steven; Ross, Bertrand; Kugler, John; Dubin, Anne M.; Sokoloski, Mary; Beerman, Lee; LeGras, Marc; Balaji, Seshadri; Porter, Coburn; Etheridge, Susan; Perry, James C.; Cecchin, Frank; Zimmerman, Frank; Bromberg, Burt; Byrum, Craig; Samson, Ricardo; Hamilton, Robert; Moak, Jeff.

In: Heart Rhythm, Vol. 1, No. 2, 07.2004, p. 188-196.

Research output: Contribution to journalArticle

Van Hare, GF, Javitz, H, Carmelli, D, Saul, JP, Tanel, RE, Fischbach, PS, Kanter, RJ, Schaffer, M, Dunnigan, A, Colan, S, Serwer, G, Dick, M, Campbell, R, Lau, YR, Walsh, EP, Knilans, T, Scott, W, Park, J, Karpawich, P, Bell, M, Friedman, R, Weindling, S, Erickson, C, Sehra, R, Shannon, KM, Young, ML, Fish, F, Fishberger, S, Ross, B, Kugler, J, Dubin, AM, Sokoloski, M, Beerman, L, LeGras, M, Balaji, S, Porter, C, Etheridge, S, Perry, JC, Cecchin, F, Zimmerman, F, Bromberg, B, Byrum, C, Samson, R, Hamilton, R & Moak, J 2004, 'Prospective assessment after pediatric cardiac ablation: Recurrence at 1 year after initially successful ablation of supraventricular tachycardia', Heart Rhythm, vol. 1, no. 2, pp. 188-196. https://doi.org/10.1016/j.hrthm.2004.03.067
Van Hare, George F. ; Javitz, Harold ; Carmelli, Dorit ; Saul, J. Philip ; Tanel, Ronn E. ; Fischbach, Peter S. ; Kanter, Ronald J. ; Schaffer, Michael ; Dunnigan, Ann ; Colan, Steven ; Serwer, Gerald ; Dick, Macdonald ; Campbell, Robert ; Lau, Yung R. ; Walsh, Edward P. ; Knilans, Timothy ; Scott, William ; Park, Jeanny ; Karpawich, Peter ; Bell, Margaret ; Friedman, Richard ; Weindling, Steven ; Erickson, Christopher ; Sehra, Ruchir ; Shannon, Kevin M. ; Young, Ming Lon ; Fish, Frank ; Fishberger, Steven ; Ross, Bertrand ; Kugler, John ; Dubin, Anne M. ; Sokoloski, Mary ; Beerman, Lee ; LeGras, Marc ; Balaji, Seshadri ; Porter, Coburn ; Etheridge, Susan ; Perry, James C. ; Cecchin, Frank ; Zimmerman, Frank ; Bromberg, Burt ; Byrum, Craig ; Samson, Ricardo ; Hamilton, Robert ; Moak, Jeff. / Prospective assessment after pediatric cardiac ablation : Recurrence at 1 year after initially successful ablation of supraventricular tachycardia. In: Heart Rhythm. 2004 ; Vol. 1, No. 2. pp. 188-196.
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abstract = "Objectives. A multicenter prospective study was performed to assess the results and risks associated with radiofrequency ablation in children. This report focuses on recurrences following initially successful ablation. Methods. Patients recruited for the study were aged 0 to 16 years and had supraventricular tachycardia due to accessory pathways or atrioventricular nodal reentrant tachycardia (AVNRT), excluding patients with more than trivial congenital heart disease. A total of 481 patients were recruited into the prospective cohort and were followed at 2, 6, and 12 months following ablation. Results. There were 517 successfully ablated substrates out of 540 attempted (95.7{\%}). Loss to follow-up for individual substrates was 3.3{\%}, 10.6{\%}, and 21.2{\%} at 2, 6, and 12 months, respectively. Recurrence was observed in 7.0{\%}, 9.2{\%}, and 10.7{\%} of these substrates at 2, 6, and 12 months, respectively (adjusted for loss to follow-up as an independent source of data censoring). Recurrence rate varied by substrate location (24.6{\%} for right septal, 15.8{\%} for right free wall, 9.3{\%} for left free wall, and 4.8{\%} for left septal), as well as for AVNRT versus all others (4.8{\%} vs 12.9{\%}) at 12 months. The recurrence rate was higher for substrates ablated using power control but was not a function of whether isoproterenol was used for postablation testing. Conclusions. Recurrence after initially successful ablation occurs commonly in children. It is least common after AVNRT ablation and most common following ablation of right-sided pathways. These results serve as a benchmark for the time course of recurrence following initially successful ablation of supraventricular tachycardia in children.",
keywords = "Ablation, Atrioventricular nodal reentry, Children, Recurrence, Registry, Wolff-Parkinson-White syndrome",
author = "{Van Hare}, {George F.} and Harold Javitz and Dorit Carmelli and Saul, {J. Philip} and Tanel, {Ronn E.} and Fischbach, {Peter S.} and Kanter, {Ronald J.} and Michael Schaffer and Ann Dunnigan and Steven Colan and Gerald Serwer and Macdonald Dick and Robert Campbell and Lau, {Yung R.} and Walsh, {Edward P.} and Timothy Knilans and William Scott and Jeanny Park and Peter Karpawich and Margaret Bell and Richard Friedman and Steven Weindling and Christopher Erickson and Ruchir Sehra and Shannon, {Kevin M.} and Young, {Ming Lon} and Frank Fish and Steven Fishberger and Bertrand Ross and John Kugler and Dubin, {Anne M.} and Mary Sokoloski and Lee Beerman and Marc LeGras and Seshadri Balaji and Coburn Porter and Susan Etheridge and Perry, {James C.} and Frank Cecchin and Frank Zimmerman and Burt Bromberg and Craig Byrum and Ricardo Samson and Robert Hamilton and Jeff Moak",
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TY - JOUR

T1 - Prospective assessment after pediatric cardiac ablation

T2 - Recurrence at 1 year after initially successful ablation of supraventricular tachycardia

AU - Van Hare, George F.

AU - Javitz, Harold

AU - Carmelli, Dorit

AU - Saul, J. Philip

AU - Tanel, Ronn E.

AU - Fischbach, Peter S.

AU - Kanter, Ronald J.

AU - Schaffer, Michael

AU - Dunnigan, Ann

AU - Colan, Steven

AU - Serwer, Gerald

AU - Dick, Macdonald

AU - Campbell, Robert

AU - Lau, Yung R.

AU - Walsh, Edward P.

AU - Knilans, Timothy

AU - Scott, William

AU - Park, Jeanny

AU - Karpawich, Peter

AU - Bell, Margaret

AU - Friedman, Richard

AU - Weindling, Steven

AU - Erickson, Christopher

AU - Sehra, Ruchir

AU - Shannon, Kevin M.

AU - Young, Ming Lon

AU - Fish, Frank

AU - Fishberger, Steven

AU - Ross, Bertrand

AU - Kugler, John

AU - Dubin, Anne M.

AU - Sokoloski, Mary

AU - Beerman, Lee

AU - LeGras, Marc

AU - Balaji, Seshadri

AU - Porter, Coburn

AU - Etheridge, Susan

AU - Perry, James C.

AU - Cecchin, Frank

AU - Zimmerman, Frank

AU - Bromberg, Burt

AU - Byrum, Craig

AU - Samson, Ricardo

AU - Hamilton, Robert

AU - Moak, Jeff

PY - 2004/7

Y1 - 2004/7

N2 - Objectives. A multicenter prospective study was performed to assess the results and risks associated with radiofrequency ablation in children. This report focuses on recurrences following initially successful ablation. Methods. Patients recruited for the study were aged 0 to 16 years and had supraventricular tachycardia due to accessory pathways or atrioventricular nodal reentrant tachycardia (AVNRT), excluding patients with more than trivial congenital heart disease. A total of 481 patients were recruited into the prospective cohort and were followed at 2, 6, and 12 months following ablation. Results. There were 517 successfully ablated substrates out of 540 attempted (95.7%). Loss to follow-up for individual substrates was 3.3%, 10.6%, and 21.2% at 2, 6, and 12 months, respectively. Recurrence was observed in 7.0%, 9.2%, and 10.7% of these substrates at 2, 6, and 12 months, respectively (adjusted for loss to follow-up as an independent source of data censoring). Recurrence rate varied by substrate location (24.6% for right septal, 15.8% for right free wall, 9.3% for left free wall, and 4.8% for left septal), as well as for AVNRT versus all others (4.8% vs 12.9%) at 12 months. The recurrence rate was higher for substrates ablated using power control but was not a function of whether isoproterenol was used for postablation testing. Conclusions. Recurrence after initially successful ablation occurs commonly in children. It is least common after AVNRT ablation and most common following ablation of right-sided pathways. These results serve as a benchmark for the time course of recurrence following initially successful ablation of supraventricular tachycardia in children.

AB - Objectives. A multicenter prospective study was performed to assess the results and risks associated with radiofrequency ablation in children. This report focuses on recurrences following initially successful ablation. Methods. Patients recruited for the study were aged 0 to 16 years and had supraventricular tachycardia due to accessory pathways or atrioventricular nodal reentrant tachycardia (AVNRT), excluding patients with more than trivial congenital heart disease. A total of 481 patients were recruited into the prospective cohort and were followed at 2, 6, and 12 months following ablation. Results. There were 517 successfully ablated substrates out of 540 attempted (95.7%). Loss to follow-up for individual substrates was 3.3%, 10.6%, and 21.2% at 2, 6, and 12 months, respectively. Recurrence was observed in 7.0%, 9.2%, and 10.7% of these substrates at 2, 6, and 12 months, respectively (adjusted for loss to follow-up as an independent source of data censoring). Recurrence rate varied by substrate location (24.6% for right septal, 15.8% for right free wall, 9.3% for left free wall, and 4.8% for left septal), as well as for AVNRT versus all others (4.8% vs 12.9%) at 12 months. The recurrence rate was higher for substrates ablated using power control but was not a function of whether isoproterenol was used for postablation testing. Conclusions. Recurrence after initially successful ablation occurs commonly in children. It is least common after AVNRT ablation and most common following ablation of right-sided pathways. These results serve as a benchmark for the time course of recurrence following initially successful ablation of supraventricular tachycardia in children.

KW - Ablation

KW - Atrioventricular nodal reentry

KW - Children

KW - Recurrence

KW - Registry

KW - Wolff-Parkinson-White syndrome

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DO - 10.1016/j.hrthm.2004.03.067

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