Prospective, long-term study of fat-soluble vitamin status in children with cystic fibrosis identified by newborn screen

A. P. Feranchak, M. K. Sontag, J. S. Wagener, K. B. Hammond, F. J. Accurso, R. J. Sokol

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Objective: To prospectively evaluate the biochemical status of vitamins A, D, and E in children with cystic fibrosis (CF). Subjects: A total of 127 infants identified by the Colorado CF newborn screening program. Design: Vitamin status (serum retinol, 25-hydroxy vitamin D, ratio of alpha- tocopherol/total lipids) and serum albumin were assessed at diagnosis (4 to 8 weeks), ages 6 months, 12 months, and yearly thereafter, to age 10 years. Results: Deficiency of 1 or more vitamins was present in 44 (45.8%) of 96 patients at age 4 to 8 weeks as follows: vitamin A 29.0%, vitamin D 22.5%, and vitamin E 22.8%. Of these patients with initial deficiency, the percent that was deficient at 1 or more subsequent time points, despite supplementation, was vitamin A 11.1%, vitamin D 12.5%, and vitamin E 57.1%. Of the initial patients with vitamin sufficiency, the percent who became deficient at any time during the 10-year period was as follows: vitamin A 4.5%, vitamin D 14.4%, and vitamin E 11.8%. The percent of patients deficient for 1 or more vitamins ranged from 4% to 45% for any given year. Conclusions: Despite supplementation with standard multivitamins and pancreatic enzymes, the sporadic occurrence of fat-soluble vitamin deficiency and persistent deficiency is relatively common. Frequent and serial monitoring of the serum concentrations of these vitamins is therefore essential in children with CF.

Original languageEnglish (US)
Pages (from-to)601-610
Number of pages10
JournalJournal of Pediatrics
Volume135
Issue number5
StatePublished - 1999

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Vitamin A
Cystic Fibrosis
Vitamin D
Vitamins
Vitamin E
Fats
Newborn Infant
Avitaminosis
alpha-Tocopherol
Serum
Serum Albumin
Lipids
Enzymes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Feranchak, A. P., Sontag, M. K., Wagener, J. S., Hammond, K. B., Accurso, F. J., & Sokol, R. J. (1999). Prospective, long-term study of fat-soluble vitamin status in children with cystic fibrosis identified by newborn screen. Journal of Pediatrics, 135(5), 601-610.

Prospective, long-term study of fat-soluble vitamin status in children with cystic fibrosis identified by newborn screen. / Feranchak, A. P.; Sontag, M. K.; Wagener, J. S.; Hammond, K. B.; Accurso, F. J.; Sokol, R. J.

In: Journal of Pediatrics, Vol. 135, No. 5, 1999, p. 601-610.

Research output: Contribution to journalArticle

Feranchak, AP, Sontag, MK, Wagener, JS, Hammond, KB, Accurso, FJ & Sokol, RJ 1999, 'Prospective, long-term study of fat-soluble vitamin status in children with cystic fibrosis identified by newborn screen', Journal of Pediatrics, vol. 135, no. 5, pp. 601-610.
Feranchak AP, Sontag MK, Wagener JS, Hammond KB, Accurso FJ, Sokol RJ. Prospective, long-term study of fat-soluble vitamin status in children with cystic fibrosis identified by newborn screen. Journal of Pediatrics. 1999;135(5):601-610.
Feranchak, A. P. ; Sontag, M. K. ; Wagener, J. S. ; Hammond, K. B. ; Accurso, F. J. ; Sokol, R. J. / Prospective, long-term study of fat-soluble vitamin status in children with cystic fibrosis identified by newborn screen. In: Journal of Pediatrics. 1999 ; Vol. 135, No. 5. pp. 601-610.
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AB - Objective: To prospectively evaluate the biochemical status of vitamins A, D, and E in children with cystic fibrosis (CF). Subjects: A total of 127 infants identified by the Colorado CF newborn screening program. Design: Vitamin status (serum retinol, 25-hydroxy vitamin D, ratio of alpha- tocopherol/total lipids) and serum albumin were assessed at diagnosis (4 to 8 weeks), ages 6 months, 12 months, and yearly thereafter, to age 10 years. Results: Deficiency of 1 or more vitamins was present in 44 (45.8%) of 96 patients at age 4 to 8 weeks as follows: vitamin A 29.0%, vitamin D 22.5%, and vitamin E 22.8%. Of these patients with initial deficiency, the percent that was deficient at 1 or more subsequent time points, despite supplementation, was vitamin A 11.1%, vitamin D 12.5%, and vitamin E 57.1%. Of the initial patients with vitamin sufficiency, the percent who became deficient at any time during the 10-year period was as follows: vitamin A 4.5%, vitamin D 14.4%, and vitamin E 11.8%. The percent of patients deficient for 1 or more vitamins ranged from 4% to 45% for any given year. Conclusions: Despite supplementation with standard multivitamins and pancreatic enzymes, the sporadic occurrence of fat-soluble vitamin deficiency and persistent deficiency is relatively common. Frequent and serial monitoring of the serum concentrations of these vitamins is therefore essential in children with CF.

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