Prospective randomized trial of empiric therapy with trimethoprim- sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus

Mary Jo Cenizal, Daniel Skiest, Samuel Luber, Roger Bedimo, Pat Davis, Patrick Fox, Kathleen Delaney, R. Doug Hardy

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

To evaluate empirical therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus, a randomized, prospective, open-label investigation was performed. The overall clinical failure rate was 9%, with all failures occurring in the trimethoprim- sulfamethoxazole group. However, there was no significant difference between the clinical failure rate of empirical trimethoprim-sulfamethoxazole therapy and that of doxycycline therapy.

Original languageEnglish (US)
Pages (from-to)2628-2630
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number7
DOIs
StatePublished - Jul 2007

Fingerprint

Soft Tissue Infections
Doxycycline
Sulfamethoxazole Drug Combination Trimethoprim
Methicillin-Resistant Staphylococcus aureus
Outpatients
Skin
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Prospective randomized trial of empiric therapy with trimethoprim- sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus. / Cenizal, Mary Jo; Skiest, Daniel; Luber, Samuel; Bedimo, Roger; Davis, Pat; Fox, Patrick; Delaney, Kathleen; Hardy, R. Doug.

In: Antimicrobial Agents and Chemotherapy, Vol. 51, No. 7, 07.2007, p. 2628-2630.

Research output: Contribution to journalArticle

@article{40eb211adb2743d0acefd13c2966bc59,
title = "Prospective randomized trial of empiric therapy with trimethoprim- sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus",
abstract = "To evaluate empirical therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus, a randomized, prospective, open-label investigation was performed. The overall clinical failure rate was 9{\%}, with all failures occurring in the trimethoprim- sulfamethoxazole group. However, there was no significant difference between the clinical failure rate of empirical trimethoprim-sulfamethoxazole therapy and that of doxycycline therapy.",
author = "Cenizal, {Mary Jo} and Daniel Skiest and Samuel Luber and Roger Bedimo and Pat Davis and Patrick Fox and Kathleen Delaney and Hardy, {R. Doug}",
year = "2007",
month = "7",
doi = "10.1128/AAC.00206-07",
language = "English (US)",
volume = "51",
pages = "2628--2630",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "7",

}

TY - JOUR

T1 - Prospective randomized trial of empiric therapy with trimethoprim- sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus

AU - Cenizal, Mary Jo

AU - Skiest, Daniel

AU - Luber, Samuel

AU - Bedimo, Roger

AU - Davis, Pat

AU - Fox, Patrick

AU - Delaney, Kathleen

AU - Hardy, R. Doug

PY - 2007/7

Y1 - 2007/7

N2 - To evaluate empirical therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus, a randomized, prospective, open-label investigation was performed. The overall clinical failure rate was 9%, with all failures occurring in the trimethoprim- sulfamethoxazole group. However, there was no significant difference between the clinical failure rate of empirical trimethoprim-sulfamethoxazole therapy and that of doxycycline therapy.

AB - To evaluate empirical therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus, a randomized, prospective, open-label investigation was performed. The overall clinical failure rate was 9%, with all failures occurring in the trimethoprim- sulfamethoxazole group. However, there was no significant difference between the clinical failure rate of empirical trimethoprim-sulfamethoxazole therapy and that of doxycycline therapy.

UR - http://www.scopus.com/inward/record.url?scp=34447251601&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447251601&partnerID=8YFLogxK

U2 - 10.1128/AAC.00206-07

DO - 10.1128/AAC.00206-07

M3 - Article

VL - 51

SP - 2628

EP - 2630

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 7

ER -