Prospective research in infants with mild encephalopathy identified in the first six hours of life: neurodevelopmental outcomes at 18–22 months

Lina F. Chalak, Kim Anh Nguyen, Chatchay Prempunpong, Roy Heyne, Sudhin Thayyil, Seetha Shankaran, Abbot R. Laptook, Nancy Rollins, Athina Pappas, Louise Koclas, Birju Shah, Paolo Montaldo, Benyachalee Techasaensiri, Pablo J. Sánchez, Guilherme Sant’Anna

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Studies of early childhood outcomes of mild hypoxic-ischemic encephalopathy (HIE) identified in the first 6 h of life are lacking. Objective: To evaluate neurodevelopmental outcomes at 18–22 months of PRIME study. Study design: Multicenter, prospective study of mild HIE defined as ≥1 abnormality using the modified Sarnat within 6 h of birth and not meeting cooling criteria. Primary outcome was disability with mild: Bayley III cognitive 70–84 or ≥85 and either Gross Motor Function Classification System (GMFCS) 1 or 2, seizures, or hearing deficit; moderate: cognitive 70–84 and either GMFCS 2, seizures, or hearing deficit; severe: cognitive <70, GMFCS 3–5. Results: Of the 63 infants enrolled, 51 (81%) were evaluated at 19 ± 2 months and 43 (68%) completed Bayley III. Of the 43 infants, 7 (16%) were diagnosed with disability, including 1 cerebral palsy and 2 autism. Bayley scores < 85 in either cognition, motor, or language were detected in 17 (40%): 14 (32%) language, 7 (16%) cognitive, and 6 (14%) motor domain. Infants with disability had more abnormalities on discharge examination and brain MRI, with longer hospital stay (p < 0.001). Conclusions: In this contemporary untreated cohort of mild HIE, disability occurred in 16% of infants at 18–22 months.

Original languageEnglish (US)
JournalPediatric Research
DOIs
StateAccepted/In press - Jan 1 2018

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Brain Diseases
Brain Hypoxia-Ischemia
Research
Hearing
Seizures
Language
Cerebral Palsy
Autistic Disorder
Cognition
Multicenter Studies
Length of Stay
Parturition
Prospective Studies
Brain

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Prospective research in infants with mild encephalopathy identified in the first six hours of life : neurodevelopmental outcomes at 18–22 months. / Chalak, Lina F.; Nguyen, Kim Anh; Prempunpong, Chatchay; Heyne, Roy; Thayyil, Sudhin; Shankaran, Seetha; Laptook, Abbot R.; Rollins, Nancy; Pappas, Athina; Koclas, Louise; Shah, Birju; Montaldo, Paolo; Techasaensiri, Benyachalee; Sánchez, Pablo J.; Sant’Anna, Guilherme.

In: Pediatric Research, 01.01.2018.

Research output: Contribution to journalArticle

Chalak, LF, Nguyen, KA, Prempunpong, C, Heyne, R, Thayyil, S, Shankaran, S, Laptook, AR, Rollins, N, Pappas, A, Koclas, L, Shah, B, Montaldo, P, Techasaensiri, B, Sánchez, PJ & Sant’Anna, G 2018, 'Prospective research in infants with mild encephalopathy identified in the first six hours of life: neurodevelopmental outcomes at 18–22 months', Pediatric Research. https://doi.org/10.1038/s41390-018-0174-x
Chalak, Lina F. ; Nguyen, Kim Anh ; Prempunpong, Chatchay ; Heyne, Roy ; Thayyil, Sudhin ; Shankaran, Seetha ; Laptook, Abbot R. ; Rollins, Nancy ; Pappas, Athina ; Koclas, Louise ; Shah, Birju ; Montaldo, Paolo ; Techasaensiri, Benyachalee ; Sánchez, Pablo J. ; Sant’Anna, Guilherme. / Prospective research in infants with mild encephalopathy identified in the first six hours of life : neurodevelopmental outcomes at 18–22 months. In: Pediatric Research. 2018.
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abstract = "Background: Studies of early childhood outcomes of mild hypoxic-ischemic encephalopathy (HIE) identified in the first 6 h of life are lacking. Objective: To evaluate neurodevelopmental outcomes at 18–22 months of PRIME study. Study design: Multicenter, prospective study of mild HIE defined as ≥1 abnormality using the modified Sarnat within 6 h of birth and not meeting cooling criteria. Primary outcome was disability with mild: Bayley III cognitive 70–84 or ≥85 and either Gross Motor Function Classification System (GMFCS) 1 or 2, seizures, or hearing deficit; moderate: cognitive 70–84 and either GMFCS 2, seizures, or hearing deficit; severe: cognitive <70, GMFCS 3–5. Results: Of the 63 infants enrolled, 51 (81{\%}) were evaluated at 19 ± 2 months and 43 (68{\%}) completed Bayley III. Of the 43 infants, 7 (16{\%}) were diagnosed with disability, including 1 cerebral palsy and 2 autism. Bayley scores < 85 in either cognition, motor, or language were detected in 17 (40{\%}): 14 (32{\%}) language, 7 (16{\%}) cognitive, and 6 (14{\%}) motor domain. Infants with disability had more abnormalities on discharge examination and brain MRI, with longer hospital stay (p < 0.001). Conclusions: In this contemporary untreated cohort of mild HIE, disability occurred in 16{\%} of infants at 18–22 months.",
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AU - Chalak, Lina F.

AU - Nguyen, Kim Anh

AU - Prempunpong, Chatchay

AU - Heyne, Roy

AU - Thayyil, Sudhin

AU - Shankaran, Seetha

AU - Laptook, Abbot R.

AU - Rollins, Nancy

AU - Pappas, Athina

AU - Koclas, Louise

AU - Shah, Birju

AU - Montaldo, Paolo

AU - Techasaensiri, Benyachalee

AU - Sánchez, Pablo J.

AU - Sant’Anna, Guilherme

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N2 - Background: Studies of early childhood outcomes of mild hypoxic-ischemic encephalopathy (HIE) identified in the first 6 h of life are lacking. Objective: To evaluate neurodevelopmental outcomes at 18–22 months of PRIME study. Study design: Multicenter, prospective study of mild HIE defined as ≥1 abnormality using the modified Sarnat within 6 h of birth and not meeting cooling criteria. Primary outcome was disability with mild: Bayley III cognitive 70–84 or ≥85 and either Gross Motor Function Classification System (GMFCS) 1 or 2, seizures, or hearing deficit; moderate: cognitive 70–84 and either GMFCS 2, seizures, or hearing deficit; severe: cognitive <70, GMFCS 3–5. Results: Of the 63 infants enrolled, 51 (81%) were evaluated at 19 ± 2 months and 43 (68%) completed Bayley III. Of the 43 infants, 7 (16%) were diagnosed with disability, including 1 cerebral palsy and 2 autism. Bayley scores < 85 in either cognition, motor, or language were detected in 17 (40%): 14 (32%) language, 7 (16%) cognitive, and 6 (14%) motor domain. Infants with disability had more abnormalities on discharge examination and brain MRI, with longer hospital stay (p < 0.001). Conclusions: In this contemporary untreated cohort of mild HIE, disability occurred in 16% of infants at 18–22 months.

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