Prospective validation that vulnerable plaque associated with major adverse outcomes have larger plaque volume, less dense calcium, and more non-calcified plaque by quantitative, three-dimensional measurements using intravascular ultrasound with radiofrequency backscatter analysis: Results from the ATLANTA i study

Jesus G. Vazquez-Figueroa, Sarah Rinehart, Zhen Qian, Parag H. Joshi, Abhinav Sharma, James Lee, Hunt Anderson, Laura Murrieta, Charles Wilmer, Harold Carlson, Kenneth Taylor, William Ballard, Dimitri Karmpaliotis, Anna Kalynych, Charles Brown, Szilard Voros

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13 Scopus citations


Whether quantitative, two-dimensional, and three-dimensional plaque measurements by intravascular ultrasound with radiofrequency backscatter (IVUS/VH) are different between intermediate lesions with or without major adverse cardiovascular events (MACE) is unknown. IVUS/VH-derived parameters were compared in 60 patients with an intermediate coronary lesion (40-70 %) between lesions that did or did not result in MACE over 12 months. IVUS/VH measurements were done at the site of the minimal lumen area (MLA) and on a per-plaque basis, defined by 40 % plaque burden. Pre-specified, adjudicated MACE events occurred in 5 of 60 patients (8.3 %). MACE lesions had larger plaque burden (65 % vs. 53 %, p = 0.004), less dense calcium (6.6 % vs. 14.7 %, p = 0.05), and more non-calcified plaque, mostly fibrofatty kind (17.6 % vs. 10 %, p = 0.02). Intermediate coronary lesions associated with MACE at 12 months have more plaque, less dense calcium, and more non-calcified plaque, particularly fibrofatty tissue by IVUS/VH.

Original languageEnglish (US)
Pages (from-to)762-771
Number of pages10
JournalJournal of cardiovascular translational research
Issue number5
StatePublished - Oct 1 2013



  • Cardiac events
  • Intravascular ultrasound
  • Vulnerable plaque

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

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