Prostaglandin induced release of anterior pituitary hormones: structure activity relationships

J. Warberg, R. L. Eskay, J. C. Porter

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Prostaglandins (PG's) of the E, F, A, or B series were infused into a lateral ventricle of the brain of adult male rats, and the efficacy of each PG to stimulate the discharge of LH, prolactin, and TSH from the pituitary gland was determined. PGE2, PGF(2α), and PGF(2β) were found to be potent stimulators of LH release. The release was considerably less when PGE1, PGF(1β), PGA2, or PGB2 was infused. The basal release of LH was not altered by infusion of PGF(1α), PGA1, PGB1, or the control solution. It is suggested that the cis double bond in the 5,6 position and the 11 hydroxyl group are essential for the LH releasing activity of PG's and that these functional groups may be of importance for activation of a receptor at the level of the brain. Prolactin secretion was stimulated 6 to 7 fold by the infusion of 5 μg of PGE2, but 20 μg had no stimulatory effect. PGF(2β) caused a 3 to 4 fold increase in basal plasma prolactin concentration and was the only PG tested other than PGE2 that stimulated prolactin release. None of the PG's infused intraventricularly affected TSH secretion.

Original languageEnglish (US)
Pages (from-to)1135-1141
Number of pages7
JournalEndocrinology
Volume98
Issue number5
StatePublished - 1976

Fingerprint

Anterior Pituitary Hormones
Prostaglandins F
Structure-Activity Relationship
Prostaglandins
Prolactin
Dinoprostone
Alprostadil
Lateral Ventricles
Brain
Pituitary Gland
Prostaglandins E
Hydroxyl Radical

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Warberg, J., Eskay, R. L., & Porter, J. C. (1976). Prostaglandin induced release of anterior pituitary hormones: structure activity relationships. Endocrinology, 98(5), 1135-1141.

Prostaglandin induced release of anterior pituitary hormones : structure activity relationships. / Warberg, J.; Eskay, R. L.; Porter, J. C.

In: Endocrinology, Vol. 98, No. 5, 1976, p. 1135-1141.

Research output: Contribution to journalArticle

Warberg, J, Eskay, RL & Porter, JC 1976, 'Prostaglandin induced release of anterior pituitary hormones: structure activity relationships', Endocrinology, vol. 98, no. 5, pp. 1135-1141.
Warberg, J. ; Eskay, R. L. ; Porter, J. C. / Prostaglandin induced release of anterior pituitary hormones : structure activity relationships. In: Endocrinology. 1976 ; Vol. 98, No. 5. pp. 1135-1141.
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