Prostaglandins and experimental cerebral vasospasm

H. Morgan, R. P. White, M. Pennink, J. T. Robertson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Of the prostaglandins given alone in the cerebrospinal fluid, PGF(2α) caused spasm in ten of ten dogs, and PGF(1α) (also a pressor agent given intravenously) induced spasm in eight of ten dogs. PGE2 also induced spasm in seven of eight animals. Reducing the dosage of the latter to 5μg/kg similarly produced spasm in three of four animals. Spasm was evident within 15 min and usually lasted at least 2 hr. The results with PGE2 were unexpected since this agent is a depressor when given intravenously to dogs. In contrast to these compounds, PGE1 failed to produce spasm in five animals. The effect of giving PGF(2α) with blood indicates that this prostaglandin will enhance the spasmogenic properties of the latter. These results clearly demonstrate that substances present in brain tissue and the CSF can induce cerebrovascular spasm.

Original languageEnglish (US)
Pages (from-to)447-448
Number of pages2
JournalSurgical Forum
VolumeVol. 23
StatePublished - 1972

Fingerprint

Intracranial Vasospasm
Spasm
Prostaglandins
Prostaglandins F
Dogs
Dinoprostone
Alprostadil
Cerebrospinal Fluid
Brain

ASJC Scopus subject areas

  • Surgery

Cite this

Morgan, H., White, R. P., Pennink, M., & Robertson, J. T. (1972). Prostaglandins and experimental cerebral vasospasm. Surgical Forum, Vol. 23, 447-448.

Prostaglandins and experimental cerebral vasospasm. / Morgan, H.; White, R. P.; Pennink, M.; Robertson, J. T.

In: Surgical Forum, Vol. Vol. 23, 1972, p. 447-448.

Research output: Contribution to journalArticle

Morgan, H, White, RP, Pennink, M & Robertson, JT 1972, 'Prostaglandins and experimental cerebral vasospasm', Surgical Forum, vol. Vol. 23, pp. 447-448.
Morgan H, White RP, Pennink M, Robertson JT. Prostaglandins and experimental cerebral vasospasm. Surgical Forum. 1972;Vol. 23:447-448.
Morgan, H. ; White, R. P. ; Pennink, M. ; Robertson, J. T. / Prostaglandins and experimental cerebral vasospasm. In: Surgical Forum. 1972 ; Vol. Vol. 23. pp. 447-448.
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