Abstract
BACKGROUND: Prostate basal cell lesions can have architectural and cytologic atypia that mimic prostate adenocarcinoma. Immunohistochemical stains for basal cell markers are most helpful in the differential diagnosis. All of the published studies show basal cell lesions are positive for basal cell keratins, whereas adenocarcinoma is negative for both. We reported two cases of prostate basal cell lesions with negative basal cell keratin expression by immunohistochemistry. STUDY DESIGN: We reported the histologic and immunohistochemical profiles of two cases of basal cell lesions of the prostate. RESULTS: Histologically, both cases were highly suspicious for prostate adenocarcinoma with infiltrative growth pattern and significant nuclear atypia. The atypical glands in both cases were negative for basal cell keratins. However, both lesions were positive for another basal cell marker, p63, confirming that they were basal cells in origin, rather than prostate adenocarcinoma. CONCLUSION: Prostate basal cell lesions can occasionally be negative for basal cell keratins by immunohistochemistry and therefore may be misdiagnosed as prostate adenocarcinoma. We recommend using both p63 and basal cell keratins simultaneously in the workup of atypical prostate lesions to avoid such a misdiagnosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 125-129 |
| Number of pages | 5 |
| Journal | Analytical and Quantitative Cytology and Histology |
| Volume | 28 |
| Issue number | 3 |
| State | Published - Jun 1 2006 |
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Keywords
- Basal cell hyperplasia
- Basal cell keratin
- p63
- Prostate cancer
ASJC Scopus subject areas
- Anatomy
- Histology
- Cell Biology
Cite this
Prostate basal cell lesions can be negative for basal cell keratins : A diagnostic pitfall. / Zhou, Ming; Magi-Galluzzi, Cristina; Epstein, Jonathan I.
In: Analytical and Quantitative Cytology and Histology, Vol. 28, No. 3, 01.06.2006, p. 125-129.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prostate basal cell lesions can be negative for basal cell keratins
T2 - A diagnostic pitfall
AU - Zhou, Ming
AU - Magi-Galluzzi, Cristina
AU - Epstein, Jonathan I.
PY - 2006/6/1
Y1 - 2006/6/1
N2 - BACKGROUND: Prostate basal cell lesions can have architectural and cytologic atypia that mimic prostate adenocarcinoma. Immunohistochemical stains for basal cell markers are most helpful in the differential diagnosis. All of the published studies show basal cell lesions are positive for basal cell keratins, whereas adenocarcinoma is negative for both. We reported two cases of prostate basal cell lesions with negative basal cell keratin expression by immunohistochemistry. STUDY DESIGN: We reported the histologic and immunohistochemical profiles of two cases of basal cell lesions of the prostate. RESULTS: Histologically, both cases were highly suspicious for prostate adenocarcinoma with infiltrative growth pattern and significant nuclear atypia. The atypical glands in both cases were negative for basal cell keratins. However, both lesions were positive for another basal cell marker, p63, confirming that they were basal cells in origin, rather than prostate adenocarcinoma. CONCLUSION: Prostate basal cell lesions can occasionally be negative for basal cell keratins by immunohistochemistry and therefore may be misdiagnosed as prostate adenocarcinoma. We recommend using both p63 and basal cell keratins simultaneously in the workup of atypical prostate lesions to avoid such a misdiagnosis.
AB - BACKGROUND: Prostate basal cell lesions can have architectural and cytologic atypia that mimic prostate adenocarcinoma. Immunohistochemical stains for basal cell markers are most helpful in the differential diagnosis. All of the published studies show basal cell lesions are positive for basal cell keratins, whereas adenocarcinoma is negative for both. We reported two cases of prostate basal cell lesions with negative basal cell keratin expression by immunohistochemistry. STUDY DESIGN: We reported the histologic and immunohistochemical profiles of two cases of basal cell lesions of the prostate. RESULTS: Histologically, both cases were highly suspicious for prostate adenocarcinoma with infiltrative growth pattern and significant nuclear atypia. The atypical glands in both cases were negative for basal cell keratins. However, both lesions were positive for another basal cell marker, p63, confirming that they were basal cells in origin, rather than prostate adenocarcinoma. CONCLUSION: Prostate basal cell lesions can occasionally be negative for basal cell keratins by immunohistochemistry and therefore may be misdiagnosed as prostate adenocarcinoma. We recommend using both p63 and basal cell keratins simultaneously in the workup of atypical prostate lesions to avoid such a misdiagnosis.
KW - Basal cell hyperplasia
KW - Basal cell keratin
KW - p63
KW - Prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=33747193564&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33747193564&partnerID=8YFLogxK
M3 - Article
C2 - 16786721
AN - SCOPUS:33747193564
VL - 28
SP - 125
EP - 129
JO - Analytical and Quantitative Cytopathology and Histopathology
JF - Analytical and Quantitative Cytopathology and Histopathology
SN - 0301-102X
IS - 3
ER -