Prostate-derived ETS factor regulates epithelial-to-mesenchymal transition through both SLUG-dependent and independent mechanisms

Victoria J. Findlay, David P. Turner, John S. Yordy, Brent McCarragher, Marey R. Shriver, Gabor Szalai, Patricia M. Watson, Amanda C. Larue, Omar Moussa, Dennis K. Watson

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The 5-year survival rate is very low when breast cancer becomes metastatic. The metastatic process is governed by a network of molecules of which SLUG is known to play a major role as a regulator of epithelial-to-mesenchymal transition (EMT). Prostate-derived ETS factor (PDEF) has been proposed as a tumor suppressor, possibly through inhibition of invasion and metastasis; therefore, understanding the mechanism of PDEF regulation may help to better understand its role in breast cancer progression. This study shows for the first time that the transcription factor SLUG is a direct target of PDEF in breast cancer. We show that the expression of PDEF is able to suppress/dampen EMT through the negative regulation of SLUG. In addition, we show that PDEF is also able to regulate downstream targets of SLUG, namely E-cadherin, in both SLUG-dependent and -independent manners, suggesting a critical role for PDEF in regulating EMT.

Original languageEnglish (US)
Pages (from-to)120-129
Number of pages10
JournalGenes and Cancer
Volume2
Issue number2
DOIs
StatePublished - 2011

Keywords

  • Breast cancer
  • ETS transcription factors
  • Epithelial-to-mesenchymal transition
  • PDEF
  • SLUG

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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