Abstract
Prostate carcinoma (PCa) exhibits a wide range of architectural and cytological features. Gleason grading remains as one of the most powerful histological prognostic parameters. However, it has evolved considerably. High-grade prostatic intraepithelial neoplasia (high-grade PIN) is accepted as a precursor lesion to PCa. Its detection in prostate biopsy is also considered as a risk factor for detecting cancer in subsequent biopsies. Such risk, however, has significantly decreased in recent studies. Intraductal carcinoma of the prostate (IDC-P) represents the intraductal spread of invasive cancer and constitutes a poor histologic parameter. This article reviews the key histological features of PCa, high-grade PIN and IDC-P, as well as the Gleason grading system that was most recently updated in 2005.
Original language | English (US) |
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Pages (from-to) | 43-75 |
Number of pages | 33 |
Journal | Surgical Pathology Clinics |
Volume | 1 |
Issue number | 1 |
DOIs | |
State | Published - Dec 2008 |
Keywords
- Intraductal carcinoma of the prostate
- Prostatic adenocarcinoma
- Prostatic intraepithelial neoplasia
ASJC Scopus subject areas
- Surgery
- Pathology and Forensic Medicine