Proteases

Margaret A. Phillips, Robert J. Fletterick

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Proteases control many physiological responses, thus the identification and characterization of specific proteases offers the prospect of new medical adbances. Study of the structure-function relationships in protease-catalyzed hydrolysis of the peptide bond has adbanced our understanding of enzyme catalysis and specificity. Three-dimensional structures have been solved for each mechanistic class of protease, and these studies have been extended using site-directed mutagenesis to characterize the amino acid residues required for enzyme function.

Original languageEnglish (US)
Pages (from-to)713-720
Number of pages8
JournalCurrent Opinion in Structural Biology
Volume2
Issue number5
DOIs
StatePublished - Oct 1992

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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