Protection from premature habituation requires functional mushroom bodies in Drosophila.

Summer F. Acevedo, Emmanuil I. Froudarakis, Alexandros Kanellopoulos, Efthimios M C Skoulakis

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Diminished responses to stimuli defined as habituation can serve as a gating mechanism for repetitive environmental cues with little predictive value and importance. We demonstrate that wild-type animals diminish their responses to electric shock stimuli with properties characteristic of short- and long-term habituation. We used spatially restricted abrogation of neurotransmission to identify brain areas involved in this behavioral response. We find that the mushroom bodies and, in particular, the alpha/beta lobes appear to guard against habituating prematurely to repetitive electric shock stimuli. In addition to protection from premature habituation, the mushroom bodies are essential for spontaneous recovery and dishabituation. These results reveal a novel modulatory role of the mushroom bodies on responses to repetitive stimuli in agreement with and complementary to their established roles in olfactory learning and memory.

Original languageEnglish (US)
Pages (from-to)376-384
Number of pages9
JournalLearning & memory (Cold Spring Harbor, N.Y.)
Volume14
Issue number5
StatePublished - 2007

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Mushroom Bodies
Drosophila
Shock
Wild Animals
Synaptic Transmission
Cues
Learning
Brain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Acevedo, S. F., Froudarakis, E. I., Kanellopoulos, A., & Skoulakis, E. M. C. (2007). Protection from premature habituation requires functional mushroom bodies in Drosophila. Learning & memory (Cold Spring Harbor, N.Y.), 14(5), 376-384.

Protection from premature habituation requires functional mushroom bodies in Drosophila. / Acevedo, Summer F.; Froudarakis, Emmanuil I.; Kanellopoulos, Alexandros; Skoulakis, Efthimios M C.

In: Learning & memory (Cold Spring Harbor, N.Y.), Vol. 14, No. 5, 2007, p. 376-384.

Research output: Contribution to journalArticle

Acevedo, SF, Froudarakis, EI, Kanellopoulos, A & Skoulakis, EMC 2007, 'Protection from premature habituation requires functional mushroom bodies in Drosophila.', Learning & memory (Cold Spring Harbor, N.Y.), vol. 14, no. 5, pp. 376-384.
Acevedo, Summer F. ; Froudarakis, Emmanuil I. ; Kanellopoulos, Alexandros ; Skoulakis, Efthimios M C. / Protection from premature habituation requires functional mushroom bodies in Drosophila. In: Learning & memory (Cold Spring Harbor, N.Y.). 2007 ; Vol. 14, No. 5. pp. 376-384.
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