Protective effects of ferulic acid on hyperlipidemic diabetic rats

M. Sri Balasubashini; R. Rukkumani; V. P. Menon

doi:10.1007/s00592-003-0099-6

Protective effects of ferulic acid on hyperlipidemic diabetic rats

M. Sri Balasubashini, R. Rukkumani, V. P. Menon

Research output: Contribution to journal › Article › peer-review

138 Scopus citations

Abstract

Diabetes, when uncontrolled, causes dyslipidemia often followed by atherogenic abnormalities. The present study was focused to determine whether ferulic acid (FA), a flavonoid, has any role to play in diabetes-induced dyslipidemia. Diabetes in rats was induced with streptozotocin. The levels of blood glucose and plasma triglycerides (TG), free fatty acids (FFA), cholesterol and phospholipids were elevated during diabetes. Treatment with FA significantly reduced the elevated plasma lipid and blood glucose levels; a more pronounced effect was found with low-dose ferulic acid than with high dose. Thus, our study demonstrates that ferulic acid lowers the lipid levels in diabetic rats and hence prevents further complications.

Original language	English (US)
Pages (from-to)	118-122
Number of pages	5
Journal	Acta Diabetologica
Volume	40
Issue number	3
DOIs	https://doi.org/10.1007/s00592-003-0099-6
State	Published - Sep 1 2003

Keywords

Diabetes
Ferulic acid
Flavonoids
Hyperlipidemia

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1007/s00592-003-0099-6

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AB - Diabetes, when uncontrolled, causes dyslipidemia often followed by atherogenic abnormalities. The present study was focused to determine whether ferulic acid (FA), a flavonoid, has any role to play in diabetes-induced dyslipidemia. Diabetes in rats was induced with streptozotocin. The levels of blood glucose and plasma triglycerides (TG), free fatty acids (FFA), cholesterol and phospholipids were elevated during diabetes. Treatment with FA significantly reduced the elevated plasma lipid and blood glucose levels; a more pronounced effect was found with low-dose ferulic acid than with high dose. Thus, our study demonstrates that ferulic acid lowers the lipid levels in diabetic rats and hence prevents further complications.

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Protective effects of ferulic acid on hyperlipidemic diabetic rats

Abstract

Keywords

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