Protein acetylation as a means to regulate protein function in tune with metabolic state

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Protein acetylation has emerged as a prominent post-translational modification that can occur on a wide variety of proteins. The metabolite acetyl-CoA is a key intermediate in energy metabolism that also serves as the acetyl group donor in protein acetylation modifications. Therefore such acetylation modifications might be coupled to the intracellular availability of acetyl-CoA. In the present article, we summarize recent evidence suggesting that the particular protein acetylation modifications enable the regulation of protein function in tune with acetyl-CoA availability and thus the metabolic state of the cell.

Original languageEnglish (US)
Pages (from-to)1037-1042
Number of pages6
JournalBiochemical Society Transactions
Volume42
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Acetylation
Acetyl Coenzyme A
Proteins
Availability
Post Translational Protein Processing
Metabolites
Energy Metabolism

Keywords

  • Acetyl-CoA
  • Acetylation
  • Epigenetics
  • Metabolism

ASJC Scopus subject areas

  • Biochemistry

Cite this

Protein acetylation as a means to regulate protein function in tune with metabolic state. / Shi, Lei; Tu, Benjamin P.

In: Biochemical Society Transactions, Vol. 42, No. 4, 2014, p. 1037-1042.

Research output: Contribution to journalArticle

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KW - Acetyl-CoA

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