Protein acetylation as a means to regulate protein function in tune with metabolic state

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Protein acetylation has emerged as a prominent post-translational modification that can occur on a wide variety of proteins. The metabolite acetyl-CoA is a key intermediate in energy metabolism that also serves as the acetyl group donor in protein acetylation modifications. Therefore such acetylation modifications might be coupled to the intracellular availability of acetyl-CoA. In the present article, we summarize recent evidence suggesting that the particular protein acetylation modifications enable the regulation of protein function in tune with acetyl-CoA availability and thus the metabolic state of the cell.

Original languageEnglish (US)
Pages (from-to)1037-1042
Number of pages6
JournalBiochemical Society Transactions
Issue number4
StatePublished - Aug 2014



  • Acetyl-CoA
  • Acetylation
  • Epigenetics
  • Metabolism

ASJC Scopus subject areas

  • Biochemistry

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