Protein arrays for biomarker discovery in lupus

Taylor E. Hinchliffe, Zuan Tao Lin, Tianfu Wu

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Lupus is one of the most common autoimmune diseases, yet many mechanisms of its pathogenesis are not fully known. Over the last few years, advances in protein array technology have accelerated rapidly, resulting in many promising insights toward the discovery of novel lupus biomarkers that may become useful in disease diagnosis and management. Still, only two types of analytical protein arrays thus far, being antibody and antigen arrays, have found notable usage toward lupus biomarker discovery. In this review, we summarize current protein array technologies being used for biomarker discoveries in lupus and associated biomarker findings, as well as protein arrays that are likely to be used for lupus biomarker discovery in the near future.

Original languageEnglish (US)
Pages (from-to)625-634
Number of pages10
JournalProteomics - Clinical Applications
Volume10
Issue number6
DOIs
StatePublished - Jun 1 2016

Keywords

  • Aptamer
  • Diagnostics
  • Lupus
  • Plasmonics
  • Protein array

ASJC Scopus subject areas

  • Clinical Biochemistry

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