Protein kinase C β(II) isoform is up-regulated in human proliferative glomerulonephritis

Michael B. Ganz, Rima Abu-Nader, Ramesh Saxena, Joris Grond

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Abstract

Cell proliferation is a predominant feature in glomerulonephritis (GN). Recent work has suggested that protein kinase C (PKC) isoforms are responsible, specifically, PKC β(II) in part, for cell growth. PKC β(II) is expressed during cell growth in early glomerulogenesis and inflammatory mediators of glomerular disease induce PKC β(II) expression. We therefore investigated the expression of PKC β(II) in kidney biopsy specimens from patients with various types of proliferative (n = 41), nonproliferative GN (n = 23), and in structurally normal kidneys (n = 15). PKC β(II) immunoreactivity was exclusively found in proliferative GN whereas PKC expression was not detected in normal glomerular and in nonproliferative disease states. The consistent expression of PKC β(II) in proliferative GN suggests a key signaling role for this enzyme in cell proliferation in renal disease.

Original languageEnglish (US)
Pages (from-to)225-232
Number of pages8
JournalExperimental Nephrology
Volume5
Issue number3
StatePublished - May 1 1997

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Keywords

  • Glomerular disease
  • Mesangial cells
  • Proliferation
  • Protein kinase C isoforms

ASJC Scopus subject areas

  • Nephrology

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