Protein kinase C in the postmortem brain of teenage suicide victims

Ghanshyam N. Pandey, Yogesh Dwivedi, Subhash C. Pandey, Robert R. Conley, Rosalinda C. Roberts, Carol A. Tamminga

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Increased serotonin (2A) (5-HT(2A)) receptors have been reported in the postmortem brain of suicide victims. To examine if this increase is associated with the dysregulation of postreceptor sites in the signaling cascade, we determined [3H]phorbol dibutyrate (PDBU) binding to protein kinase C (PKC) in postmortem brain samples (Brodmann's areas 8 and 9) obtained from teenage suicide victims and control subjects. [3H]PDBU binding to PKC was determined in membranal and cytosolic fractions. We observed that B(max) of [3H]PDBU binding sites was significantly decreased in both membranal and cytosolic fractions in brain samples from Brodmann's areas 8-9 compared to matched controls. These results thus suggest that PKC may play a role in the pathophysiology of suicidal behavior.

Original languageEnglish (US)
Pages (from-to)111-114
Number of pages4
JournalNeuroscience letters
Volume228
Issue number2
DOIs
StatePublished - Jun 6 1997

Keywords

  • Postmortem brain
  • Protein kinase C
  • Teenage suicide

ASJC Scopus subject areas

  • Neuroscience(all)

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