Protein kinase C overactivity impairs prefrontal cortical regulation of working memory

S. G. Birnbaum, P. X. Yuan, M. Wang, S. Vijayraghavan, A. K. Bloom, D. J. Davis, K. T. Gobeske, J. D. Sweatt, H. K. Manji, A. F T Arnsten

Research output: Contribution to journalArticle

230 Scopus citations

Abstract

The prefrontal cortex is a higher brain region that regulates thought, behavior, and emotion using representational knowledge, operations often referred to as working memory. We tested the influence of protein kinase C (PKC) intracellular signaling on prefrontal cortical cognitive function and showed that high levels of PKC activity in prefrontal cortex, as seen for example during stress exposure, markedly impair behavioral and electrophysiological measures of working memory. These data suggest that excessive PKC activation can disrupt prefrontal cortical regulation of behavior and thought, possibly contributing to signs of prefrontal cortical dysfunction such as distractibility, impaired judgment, impulsivity, and thought disorder.

Original languageEnglish (US)
Pages (from-to)882-884
Number of pages3
JournalScience
Volume306
Issue number5697
DOIs
StatePublished - Oct 29 2004

ASJC Scopus subject areas

  • General

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    Birnbaum, S. G., Yuan, P. X., Wang, M., Vijayraghavan, S., Bloom, A. K., Davis, D. J., Gobeske, K. T., Sweatt, J. D., Manji, H. K., & Arnsten, A. F. T. (2004). Protein kinase C overactivity impairs prefrontal cortical regulation of working memory. Science, 306(5697), 882-884. https://doi.org/10.1126/science.1100021