Protein kinases

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

The structures of four serine/threonine protein kinases have been determined recently. By comparing these structures with that of the cAMP-dependent protein kinase (cAPK), it is now possible to see how the activity of these regulatory enzymes is controlled. Low activity is maintained through the conformation of the phosphorylation lip, domain rotations, and binding of substrate analog inhibitors and autoinhibitory domains.

Original languageEnglish (US)
Pages (from-to)833-840
Number of pages8
JournalCurrent Opinion in Structural Biology
Volume4
Issue number6
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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