Protein-Loaded Bioresorbable Fibers and Expandable Stents

Mechanical Properties and Protein Release

Meital Zilberman, Nathan D. Schwade, Robert C. Eberhart

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

There is an increasing interest in bioresorbable polymeric stents for coronary, urethral and tracheal applications. These stents can support body conduits during their healing process and release biologically active agents from an internal reservoir to the surrounding tissue. A removal operation is not needed. Bioresorbable poly(L-lactic acid) fibers were prepared through melt spinning accompanied by a postpreparation drawing process. Novel expandable bioresorbable stents were developed from these fibers. Bioresorbable microspheres containing albumin were prepared and attached to the stents, to serve as a protein reservoir coating. The controlled release of albumin from the microsphere-loaded stent was studied. The fibers combine high strength and modulus, together with good ductility and flexibility. An increase in draw ratio increases the tensile strength and modulus and decreases the ultimate strain. The stents demonstrated excellent initial radial compression strength and good in vitro degradation resistivity, which makes them applicable for supporting blood vessels for at least 20 weeks. Microspheres bound to these stents enable effective protein loading, without reducing the stent's mechanical properties. The protein release from the microsphere-loaded stent occurs by diffusion, is determined mainly by the initial molecular weight of the bioresorbable polymer and its erosion rate, and is strongly affected by the microsphere structure.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume69
Issue number1
StatePublished - Apr 15 2004

Fingerprint

Stents
Proteins
Mechanical properties
Fibers
Microspheres
Albumins
Melt spinning
Blood vessels
Lactic acid
Ductility
Erosion
Polymers
Tensile strength
Elastic moduli
Molecular weight
Tissue
Degradation
Coatings

Keywords

  • Albumin release
  • Bioresorbable fibers
  • Mechanical properties
  • Poly(L-lactic acid)
  • Stent

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Protein-Loaded Bioresorbable Fibers and Expandable Stents : Mechanical Properties and Protein Release. / Zilberman, Meital; Schwade, Nathan D.; Eberhart, Robert C.

In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 69, No. 1, 15.04.2004, p. 1-10.

Research output: Contribution to journalArticle

@article{04d23bc201b34127ba97b46570bf2853,
title = "Protein-Loaded Bioresorbable Fibers and Expandable Stents: Mechanical Properties and Protein Release",
abstract = "There is an increasing interest in bioresorbable polymeric stents for coronary, urethral and tracheal applications. These stents can support body conduits during their healing process and release biologically active agents from an internal reservoir to the surrounding tissue. A removal operation is not needed. Bioresorbable poly(L-lactic acid) fibers were prepared through melt spinning accompanied by a postpreparation drawing process. Novel expandable bioresorbable stents were developed from these fibers. Bioresorbable microspheres containing albumin were prepared and attached to the stents, to serve as a protein reservoir coating. The controlled release of albumin from the microsphere-loaded stent was studied. The fibers combine high strength and modulus, together with good ductility and flexibility. An increase in draw ratio increases the tensile strength and modulus and decreases the ultimate strain. The stents demonstrated excellent initial radial compression strength and good in vitro degradation resistivity, which makes them applicable for supporting blood vessels for at least 20 weeks. Microspheres bound to these stents enable effective protein loading, without reducing the stent's mechanical properties. The protein release from the microsphere-loaded stent occurs by diffusion, is determined mainly by the initial molecular weight of the bioresorbable polymer and its erosion rate, and is strongly affected by the microsphere structure.",
keywords = "Albumin release, Bioresorbable fibers, Mechanical properties, Poly(L-lactic acid), Stent",
author = "Meital Zilberman and Schwade, {Nathan D.} and Eberhart, {Robert C.}",
year = "2004",
month = "4",
day = "15",
language = "English (US)",
volume = "69",
pages = "1--10",
journal = "Journal of Biomedical Materials Research - Part A",
issn = "0021-9304",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Protein-Loaded Bioresorbable Fibers and Expandable Stents

T2 - Mechanical Properties and Protein Release

AU - Zilberman, Meital

AU - Schwade, Nathan D.

AU - Eberhart, Robert C.

PY - 2004/4/15

Y1 - 2004/4/15

N2 - There is an increasing interest in bioresorbable polymeric stents for coronary, urethral and tracheal applications. These stents can support body conduits during their healing process and release biologically active agents from an internal reservoir to the surrounding tissue. A removal operation is not needed. Bioresorbable poly(L-lactic acid) fibers were prepared through melt spinning accompanied by a postpreparation drawing process. Novel expandable bioresorbable stents were developed from these fibers. Bioresorbable microspheres containing albumin were prepared and attached to the stents, to serve as a protein reservoir coating. The controlled release of albumin from the microsphere-loaded stent was studied. The fibers combine high strength and modulus, together with good ductility and flexibility. An increase in draw ratio increases the tensile strength and modulus and decreases the ultimate strain. The stents demonstrated excellent initial radial compression strength and good in vitro degradation resistivity, which makes them applicable for supporting blood vessels for at least 20 weeks. Microspheres bound to these stents enable effective protein loading, without reducing the stent's mechanical properties. The protein release from the microsphere-loaded stent occurs by diffusion, is determined mainly by the initial molecular weight of the bioresorbable polymer and its erosion rate, and is strongly affected by the microsphere structure.

AB - There is an increasing interest in bioresorbable polymeric stents for coronary, urethral and tracheal applications. These stents can support body conduits during their healing process and release biologically active agents from an internal reservoir to the surrounding tissue. A removal operation is not needed. Bioresorbable poly(L-lactic acid) fibers were prepared through melt spinning accompanied by a postpreparation drawing process. Novel expandable bioresorbable stents were developed from these fibers. Bioresorbable microspheres containing albumin were prepared and attached to the stents, to serve as a protein reservoir coating. The controlled release of albumin from the microsphere-loaded stent was studied. The fibers combine high strength and modulus, together with good ductility and flexibility. An increase in draw ratio increases the tensile strength and modulus and decreases the ultimate strain. The stents demonstrated excellent initial radial compression strength and good in vitro degradation resistivity, which makes them applicable for supporting blood vessels for at least 20 weeks. Microspheres bound to these stents enable effective protein loading, without reducing the stent's mechanical properties. The protein release from the microsphere-loaded stent occurs by diffusion, is determined mainly by the initial molecular weight of the bioresorbable polymer and its erosion rate, and is strongly affected by the microsphere structure.

KW - Albumin release

KW - Bioresorbable fibers

KW - Mechanical properties

KW - Poly(L-lactic acid)

KW - Stent

UR - http://www.scopus.com/inward/record.url?scp=1642354728&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642354728&partnerID=8YFLogxK

M3 - Article

VL - 69

SP - 1

EP - 10

JO - Journal of Biomedical Materials Research - Part A

JF - Journal of Biomedical Materials Research - Part A

SN - 0021-9304

IS - 1

ER -