Protein-losing enteropathy after the modified Fontan operation: Oral prednisone treatment with biopsy and laboratory proved improvement

T. M. Zellers, K. Brown

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Protein-losing enteropathy occurs in up to 10% of patients following the modified Fontan procedure. Treatment is still controversial. We describe a female adolescent who developed protein-losing enteropathy 4 years after a modified Fontan procedure. Treatment with oral prednisone attenuated the protein loss with subsequent normalization of her serum total protein and albumin levels. Discontinuation of prednisone therapy was associated with relapse, which was again treated successfully with low-dose oral prednisone. Small bowel biopsy-proved diagnosis with improvement, relapse, and improvement again are documented, as are other useful laboratory findings.

Original languageEnglish (US)
Pages (from-to)115-117
Number of pages3
JournalPediatric Cardiology
Volume17
Issue number2
DOIs
StatePublished - 1996

Fingerprint

Protein-Losing Enteropathies
Fontan Procedure
Prednisone
Biopsy
Recurrence
Serum Albumin
Blood Proteins
Therapeutics
Proteins

Keywords

  • Fontan operation
  • Prednisone
  • Protein-losing enteropathy
  • Small bowel biopsy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

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AB - Protein-losing enteropathy occurs in up to 10% of patients following the modified Fontan procedure. Treatment is still controversial. We describe a female adolescent who developed protein-losing enteropathy 4 years after a modified Fontan procedure. Treatment with oral prednisone attenuated the protein loss with subsequent normalization of her serum total protein and albumin levels. Discontinuation of prednisone therapy was associated with relapse, which was again treated successfully with low-dose oral prednisone. Small bowel biopsy-proved diagnosis with improvement, relapse, and improvement again are documented, as are other useful laboratory findings.

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