Protein translation and signaling in human eosinophils

Stephane Esnault, Zhong Jian Shen, James S. Malter

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

We have recently reported that, unlike IL-5 and GM-CSF, IL-3 induces increased translation of a subset of mRNAs. In addition, we have demonstrated that Pin1 controls the activity of mRNA binding proteins, leading to enhanced mRNA stability, GM-CSF protein production and prolonged eosinophil (EOS) survival. In this review, discussion will include an overview of cap-dependent protein translation and its regulation by intracellular signaling pathways. We will address the more general process of mRNA post-transcriptional regulation, especially regarding mRNA binding proteins, which are critical effectors of protein translation. Furthermore, we will focus on (1) the roles of IL-3-driven sustained signaling on enhanced protein translation in EOS, (2) the mechanisms regulating mRNA binding proteins activity in EOS, and (3) the potential targeting of IL-3 signaling and the signaling leading to mRNA binding activity changes to identify therapeutic targets to treat EOS-associated diseases.

Original languageEnglish (US)
Article number150
JournalFrontiers in Medicine
Volume4
Issue numberSEP
DOIs
StatePublished - 2017

Keywords

  • Eosinophils
  • IL-3
  • Intracellular signaling
  • Pin-1
  • Protein translation
  • Ribosomal S6 protein

ASJC Scopus subject areas

  • Medicine(all)

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