TY - JOUR
T1 - Protein translation in synaptic plasticity
T2 - mGluR-LTD, Fragile X
AU - Waung, Maggie W.
AU - Huber, Kimberly M.
N1 - Funding Information:
This research was supported by the grants from the National Institutes of Health NS045711, HD052731, Autism Speaks (KMH), and the UTSW Medical Scientist Training Program T32 GM08014 (MWW).
PY - 2009/6
Y1 - 2009/6
N2 - Synaptically activated, rapid and dendritic synthesis of new proteins has long been proposed to mediate long-lasting changes at the synapse [Steward O, Schuman EM: Protein synthesis at synaptic sites on dendrites. Annu Rev Neurosci 2001, 24:299-325]. Studies of group 1 metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) have provided new insight into dendritic or local translation and plasticity. Here we highlight these exciting results and discuss how synaptic activity controls local translation, the proteins that are synthesized in dendrites, how they affect synaptic function and how altered local translational control contributes to a form of human mental retardation, Fragile X Syndrome.
AB - Synaptically activated, rapid and dendritic synthesis of new proteins has long been proposed to mediate long-lasting changes at the synapse [Steward O, Schuman EM: Protein synthesis at synaptic sites on dendrites. Annu Rev Neurosci 2001, 24:299-325]. Studies of group 1 metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) have provided new insight into dendritic or local translation and plasticity. Here we highlight these exciting results and discuss how synaptic activity controls local translation, the proteins that are synthesized in dendrites, how they affect synaptic function and how altered local translational control contributes to a form of human mental retardation, Fragile X Syndrome.
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U2 - 10.1016/j.conb.2009.03.011
DO - 10.1016/j.conb.2009.03.011
M3 - Review article
C2 - 19411173
AN - SCOPUS:68649093278
SN - 0959-4388
VL - 19
SP - 319
EP - 326
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 3
ER -