Protein tyrosine phosphatase 1B: A potential leptin resistance factor of obesity

W. S. Cook; Roger H Unger

doi:10.1016/S1534-5807(02)00158-2

Protein tyrosine phosphatase 1B: A potential leptin resistance factor of obesity

W. S. Cook, Roger H Unger

Research output: Contribution to journal › Review article › peer-review

71 Scopus citations

Abstract

Indirect evidence implicates leptin resistance in the pathogenesis of the lipotoxicity that complicates obesity and results in the metabolic syndrome. In this issue of Developmental Cell, two groups identify protein tyrosine phosphatase 1B (PTP1B) as a cause of leptin resistance through dephosphorylation of Jak2.

Original language	English (US)
Pages (from-to)	385-387
Number of pages	3
Journal	Developmental cell
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/S1534-5807(02)00158-2
State	Published - 2002

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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title = "Protein tyrosine phosphatase 1B: A potential leptin resistance factor of obesity",

abstract = "Indirect evidence implicates leptin resistance in the pathogenesis of the lipotoxicity that complicates obesity and results in the metabolic syndrome. In this issue of Developmental Cell, two groups identify protein tyrosine phosphatase 1B (PTP1B) as a cause of leptin resistance through dephosphorylation of Jak2.",

author = "Cook, {W. S.} and Unger, {Roger H}",

year = "2002",

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language = "English (US)",

volume = "2",

pages = "385--387",

journal = "Developmental cell",

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T1 - Protein tyrosine phosphatase 1B

T2 - A potential leptin resistance factor of obesity

AU - Cook, W. S.

AU - Unger, Roger H

PY - 2002

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N2 - Indirect evidence implicates leptin resistance in the pathogenesis of the lipotoxicity that complicates obesity and results in the metabolic syndrome. In this issue of Developmental Cell, two groups identify protein tyrosine phosphatase 1B (PTP1B) as a cause of leptin resistance through dephosphorylation of Jak2.

AB - Indirect evidence implicates leptin resistance in the pathogenesis of the lipotoxicity that complicates obesity and results in the metabolic syndrome. In this issue of Developmental Cell, two groups identify protein tyrosine phosphatase 1B (PTP1B) as a cause of leptin resistance through dephosphorylation of Jak2.

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U2 - 10.1016/S1534-5807(02)00158-2

DO - 10.1016/S1534-5807(02)00158-2

M3 - Review article

C2 - 11970889

AN - SCOPUS:0036230536

SN - 1534-5807

VL - 2

SP - 385

EP - 387

JO - Developmental cell

JF - Developmental cell

IS - 4

ER -

Protein tyrosine phosphatase 1B: A potential leptin resistance factor of obesity

Abstract

ASJC Scopus subject areas

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