Protein tyrosine phosphatase 1B: A potential leptin resistance factor of obesity

W. S. Cook, Roger H Unger

Research output: Contribution to journalArticle

59 Scopus citations


Indirect evidence implicates leptin resistance in the pathogenesis of the lipotoxicity that complicates obesity and results in the metabolic syndrome. In this issue of Developmental Cell, two groups identify protein tyrosine phosphatase 1B (PTP1B) as a cause of leptin resistance through dephosphorylation of Jak2.

Original languageEnglish (US)
Pages (from-to)385-387
Number of pages3
JournalDevelopmental Cell
Issue number4
Publication statusPublished - 2002


ASJC Scopus subject areas

  • Developmental Biology

Cite this