Protein tyrosine phosphatase 1B: A potential leptin resistance factor of obesity

W. S. Cook, Roger H Unger

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Indirect evidence implicates leptin resistance in the pathogenesis of the lipotoxicity that complicates obesity and results in the metabolic syndrome. In this issue of Developmental Cell, two groups identify protein tyrosine phosphatase 1B (PTP1B) as a cause of leptin resistance through dephosphorylation of Jak2.

Original languageEnglish (US)
Pages (from-to)385-387
Number of pages3
JournalDevelopmental Cell
Volume2
Issue number4
DOIs
StatePublished - 2002

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Non-Receptor Type 1 Protein Tyrosine Phosphatase
R Factors
Leptin
Obesity

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Protein tyrosine phosphatase 1B : A potential leptin resistance factor of obesity. / Cook, W. S.; Unger, Roger H.

In: Developmental Cell, Vol. 2, No. 4, 2002, p. 385-387.

Research output: Contribution to journalArticle

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