Abstract
The targets of receptor protein-tyrosine kinases are characterized by Src homology 2 (SH2) domains, that mediate specific interactions with receptor autophosphorylation sites. SH2-mediated interactions are important for the activation of biochemical signalling pathways in cells stimulated with growth factors. A distinct protein module, the SH3 domain, is frequently found in polypeptides that contain SH2 domains, and is also implicated in controlling protein-protein interactions in signal transduction. Evidence suggesting that SH2 and SH3 domains act synergistically in stimulation of the Ras pathway is discussed.
Original language | English (US) |
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Pages (from-to) | 279-285 |
Number of pages | 7 |
Journal | Philosophical transactions of the Royal Society of London. Series B, Biological sciences |
Volume | 340 |
Issue number | 1293 |
DOIs | |
State | Published - Jun 29 1993 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)