Proteins with SH2 and SH3 domains couple receptor tyrosine kinases to intracellular signalling pathways.

T. Pawson, P. Olivier, M. Rozakis-Adcock, J. McGlade, M. Henkemeyer

Research output: Contribution to journalReview article

48 Scopus citations


The targets of receptor protein-tyrosine kinases are characterized by Src homology 2 (SH2) domains, that mediate specific interactions with receptor autophosphorylation sites. SH2-mediated interactions are important for the activation of biochemical signalling pathways in cells stimulated with growth factors. A distinct protein module, the SH3 domain, is frequently found in polypeptides that contain SH2 domains, and is also implicated in controlling protein-protein interactions in signal transduction. Evidence suggesting that SH2 and SH3 domains act synergistically in stimulation of the Ras pathway is discussed.

Original languageEnglish (US)
Pages (from-to)279-285
Number of pages7
JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
Issue number1293
StatePublished - Jun 29 1993


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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