Proteins with SH2 and SH3 domains couple receptor tyrosine kinases to intracellular signalling pathways

T. Pawson, P. Olivier, M. Rozakis-Adcock, J. McGlade, M. Henkemeyer

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

The targets of receptor protein-tyrosine kinases are characterized by Src homology 2 (SH2) domains, that mediate specific interactions with receptor autophosphorylation sites. SH 2-mediated interactions are important for the activation of biochemical signalling pathways in cells stimulated with growth factors. A distinct protein module, the SH3 domain, is frequently found in polypeptides that contain SH2 domains, and is also implicated in controlling protein-protein interactions in signal transduction. Evidence suggesting that SH2 and SH3 domains act synergistically in stimulation of the Ras pathway is discussed.

Original languageEnglish (US)
Pages (from-to)279-285
Number of pages7
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume340
Issue number1293
DOIs
StatePublished - Jun 29 1993

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences

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