Proton and multinuclear magnetic resonance spectroscopy in the human brain at ultra-high field strength: A review

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Abstract

Magnetic Resonance Spectroscopy (MRS) allows for a non-invasive and non-ionizing determination of in vivo tissue concentrations and metabolic turn-over rates of more than 20 metabolites and compounds in the central nervous system of humans. The aim of this review is to give a comprehensive overview about the advantages, challenges and advances of ultra-high field MRS with regard to methodological development, discoveries and applications from its beginnings around 15 years ago up to the current state. The review is limited to human brain and spinal cord application at field strength of 7T and 9.4T and includes all relevant nuclei (1H, 31P, 13C).

Original languageEnglish (US)
Pages (from-to)181-198
Number of pages18
JournalNeuroImage
Volume168
DOIs
StatePublished - Mar 2018
Externally publishedYes

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Keywords

  • 13C
  • 1H
  • 31P
  • 7T
  • 9.4T
  • Brain
  • Human
  • Magnetic resonance spectroscopy
  • MRS
  • MRSI
  • Multi-nuclear
  • Proton

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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