Proton magnetic resonance spectroscopy of brain metabolites in galactosemia

Zhiyue J. Wang, Gerard T. Berry, Steffi F. Dreha, Huaqing Zhao, Stanton Segal, Robert A. Zimmerman

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Brain edema may occur in infants with galactosemia and has been associated with accumulation of galactitol. Proton magnetic resonance spectra were obtained from 12 patients (four newly diagnosed neonates and eight patients on galactose-restricted diets, age range 1.7-47 years) and control subjects to measure brain galactitol levels in vivo and correlate them with urinary galactitol excretion. The results demonstrate that a markedly elevated brain galactitol level may be present only in newborn infants with galactosemia who exhibit massive urinary galactitol excretion.

Original languageEnglish (US)
Pages (from-to)266-269
Number of pages4
JournalAnnals of Neurology
Volume50
Issue number2
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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