Abstract
This report reviews the physiology of gastric acid suppression by proton pump inhibitors (PPIs) and anti-inflammatory effects of PPIs that are independent of their acid-suppressive effects. Valid indications for PPI use are discussed, as are putative adverse effects of PPIs that have been identified through weak associations in observational studies that cannot establish cause-and-effect relationships. Although evidence supporting the validity of these adverse effects is weak, there is also insufficient evidence to dismiss the risks. The report emphasizes how PPIs frequently are prescribed inappropriately and encourages physicians to carefully consider the indication for PPI therapy in their patients.
| Original language | English (US) |
|---|---|
| Journal | Medical Clinics of North America |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- Complications
- Gastroesophageal reflux disease
- Peptic ulcer disease
- Proton pump inhibitor
ASJC Scopus subject areas
- Medicine(all)
Cite this
Proton Pump Inhibitors : What the Internist Needs to Know. / Spechler, Stuart J.
In: Medical Clinics of North America, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Proton Pump Inhibitors
T2 - What the Internist Needs to Know
AU - Spechler, Stuart J
PY - 2018/1/1
Y1 - 2018/1/1
N2 - This report reviews the physiology of gastric acid suppression by proton pump inhibitors (PPIs) and anti-inflammatory effects of PPIs that are independent of their acid-suppressive effects. Valid indications for PPI use are discussed, as are putative adverse effects of PPIs that have been identified through weak associations in observational studies that cannot establish cause-and-effect relationships. Although evidence supporting the validity of these adverse effects is weak, there is also insufficient evidence to dismiss the risks. The report emphasizes how PPIs frequently are prescribed inappropriately and encourages physicians to carefully consider the indication for PPI therapy in their patients.
AB - This report reviews the physiology of gastric acid suppression by proton pump inhibitors (PPIs) and anti-inflammatory effects of PPIs that are independent of their acid-suppressive effects. Valid indications for PPI use are discussed, as are putative adverse effects of PPIs that have been identified through weak associations in observational studies that cannot establish cause-and-effect relationships. Although evidence supporting the validity of these adverse effects is weak, there is also insufficient evidence to dismiss the risks. The report emphasizes how PPIs frequently are prescribed inappropriately and encourages physicians to carefully consider the indication for PPI therapy in their patients.
KW - Complications
KW - Gastroesophageal reflux disease
KW - Peptic ulcer disease
KW - Proton pump inhibitor
UR - http://www.scopus.com/inward/record.url?scp=85055208862&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055208862&partnerID=8YFLogxK
U2 - 10.1016/j.mcna.2018.08.001
DO - 10.1016/j.mcna.2018.08.001
M3 - Article
C2 - 30466666
AN - SCOPUS:85055208862
JO - Medical Clinics of North America
JF - Medical Clinics of North America
SN - 0025-7125
ER -