Proton translocating ATPases: Issues in structure and function

D. K. Stone, X. S. Xie

Research output: Contribution to journalEditorial

38 Scopus citations

Abstract

In this general overview of a new class of electrogenic proton translocating ATPases, assembled evidence indicates that these proton pumps are distant ancestors of classic F 1 F 0 type ATPases. As pointed out, definition of the precise mechanisms by which these proton pumps in general, and the renal proton pump(s) in particular operate and are regulated awaits considerable work. Resolution of certain key issues, notably endomembrane H + ATPase microheterogeneity, molecular structure and cellular regulation are likely to result in implications pertinent not only to renal physiology, but also to basic issues in cellular and molecular biology.

Original languageEnglish (US)
Pages (from-to)767-774
Number of pages8
JournalKidney international
Volume33
Issue number4
DOIs
StatePublished - Jan 1 1988

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ASJC Scopus subject areas

  • Nephrology

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