Proximal superficial femoral artery occlusion, collateral vessels, and walking performance in peripheral artery disease

Mary M. McDermott, Timothy J. Carroll, Melina Kibbe, Christopher M. Kramer, Kiang Liu, Jack M. Guralnik, Aoife N. Keeling, Michael H. Criqui, Luigi Ferrucci, Chun Yuan, Lu Tian, Yihua Liao, Jarett Berry, Lihui Zhao, James Carr

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objectives: We studied associations of magnetic resonance imaging (MRI)-measured superficial femoral artery (SFA) occlusions with functional performance, leg symptoms, and collateral vessel number in peripheral artery disease (PAD). We studied associations of collateral vessel number with functional performance in PAD. Background: Associations of MRI-detected SFA occlusion and collateral vessel number with functional performance among individuals with PAD have not been reported. Methods: A total of 457 participants with an ankle brachial index (ABI) <1.00 had MRI measurement of the proximal SFA with 12 consecutive 2.5-μm cross-sectional images. An occluded SFA was defined as an SFA in which at least 1 segment was occluded. A nonoccluded SFA was defined as absence of any occluded slices. Collateral vessels were visualized with magnetic resonance angiography. Lower extremity functional performance was measured with the 6-min walk, 4-m walking velocity at usual and fastest pace, and the Short Physical Performance Battery (SPPB) (0 to 12 scale, 12 = best). Results: Adjusting for age, sex, race, comorbidities, and other confounders, the presence of an SFA occlusion was associated with poorer 6-min walk performance (1,031 vs. 1,169 feet, p = 0.006), slower fast-paced walking velocity (1.15 vs. 1.22 m/s, p = 0.042), and lower SPPB score (9.07 vs. 9.75, p = 0.038) compared with the absence of an SFA occlusion. More numerous collateral vessels were associated with better 6-min walk performance (0 to 3 collaterals - 1,064 feet, 4 to 7 collaterals - 1,165 feet, ≥8 collaterals - 1,246 feet, p trend = 0.007), faster usual-paced walking speed (0 to 3 collaterals - 0.84 m/s, 4 to 7 collaterals - 0.88 m/s, ≥8 collaterals - 0.91 m/s, p trend = 0.029), and faster rapid-paced walking speed (0 to 3 collaterals - 1.17 m/s, 4 to 7 collaterals - 1.22 m/s, ≥8 collaterals - 1.29 m/s, p trend = 0.002), adjusting for age, sex, race, comorbidities, ABI, and other confounders. Conclusions: Among PAD participants, MRI-visualized occlusions in the proximal SFA are associated with poorer functional performance, whereas more numerous collaterals are associated with better functional performance. (Magnetic Resonance Imaging to Identify Characteristics of Plaque Build-Up in People With Peripheral Arterial Disease; NCT00520312)

Original languageEnglish (US)
Pages (from-to)687-694
Number of pages8
JournalJACC: Cardiovascular Imaging
Volume6
Issue number6
DOIs
StatePublished - Jun 2013

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Peripheral Arterial Disease
Femoral Artery
Walking
Magnetic Resonance Imaging
Ankle Brachial Index
Comorbidity
Magnetic Resonance Angiography
Lower Extremity
Leg

Keywords

  • atherosclerotic plaque
  • intermittent claudication
  • peripheral arterial disease
  • physical functioning

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

McDermott, M. M., Carroll, T. J., Kibbe, M., Kramer, C. M., Liu, K., Guralnik, J. M., ... Carr, J. (2013). Proximal superficial femoral artery occlusion, collateral vessels, and walking performance in peripheral artery disease. JACC: Cardiovascular Imaging, 6(6), 687-694. https://doi.org/10.1016/j.jcmg.2012.10.024

Proximal superficial femoral artery occlusion, collateral vessels, and walking performance in peripheral artery disease. / McDermott, Mary M.; Carroll, Timothy J.; Kibbe, Melina; Kramer, Christopher M.; Liu, Kiang; Guralnik, Jack M.; Keeling, Aoife N.; Criqui, Michael H.; Ferrucci, Luigi; Yuan, Chun; Tian, Lu; Liao, Yihua; Berry, Jarett; Zhao, Lihui; Carr, James.

In: JACC: Cardiovascular Imaging, Vol. 6, No. 6, 06.2013, p. 687-694.

Research output: Contribution to journalArticle

McDermott, MM, Carroll, TJ, Kibbe, M, Kramer, CM, Liu, K, Guralnik, JM, Keeling, AN, Criqui, MH, Ferrucci, L, Yuan, C, Tian, L, Liao, Y, Berry, J, Zhao, L & Carr, J 2013, 'Proximal superficial femoral artery occlusion, collateral vessels, and walking performance in peripheral artery disease', JACC: Cardiovascular Imaging, vol. 6, no. 6, pp. 687-694. https://doi.org/10.1016/j.jcmg.2012.10.024
McDermott, Mary M. ; Carroll, Timothy J. ; Kibbe, Melina ; Kramer, Christopher M. ; Liu, Kiang ; Guralnik, Jack M. ; Keeling, Aoife N. ; Criqui, Michael H. ; Ferrucci, Luigi ; Yuan, Chun ; Tian, Lu ; Liao, Yihua ; Berry, Jarett ; Zhao, Lihui ; Carr, James. / Proximal superficial femoral artery occlusion, collateral vessels, and walking performance in peripheral artery disease. In: JACC: Cardiovascular Imaging. 2013 ; Vol. 6, No. 6. pp. 687-694.
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T1 - Proximal superficial femoral artery occlusion, collateral vessels, and walking performance in peripheral artery disease

AU - McDermott, Mary M.

AU - Carroll, Timothy J.

AU - Kibbe, Melina

AU - Kramer, Christopher M.

AU - Liu, Kiang

AU - Guralnik, Jack M.

AU - Keeling, Aoife N.

AU - Criqui, Michael H.

AU - Ferrucci, Luigi

AU - Yuan, Chun

AU - Tian, Lu

AU - Liao, Yihua

AU - Berry, Jarett

AU - Zhao, Lihui

AU - Carr, James

PY - 2013/6

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N2 - Objectives: We studied associations of magnetic resonance imaging (MRI)-measured superficial femoral artery (SFA) occlusions with functional performance, leg symptoms, and collateral vessel number in peripheral artery disease (PAD). We studied associations of collateral vessel number with functional performance in PAD. Background: Associations of MRI-detected SFA occlusion and collateral vessel number with functional performance among individuals with PAD have not been reported. Methods: A total of 457 participants with an ankle brachial index (ABI) <1.00 had MRI measurement of the proximal SFA with 12 consecutive 2.5-μm cross-sectional images. An occluded SFA was defined as an SFA in which at least 1 segment was occluded. A nonoccluded SFA was defined as absence of any occluded slices. Collateral vessels were visualized with magnetic resonance angiography. Lower extremity functional performance was measured with the 6-min walk, 4-m walking velocity at usual and fastest pace, and the Short Physical Performance Battery (SPPB) (0 to 12 scale, 12 = best). Results: Adjusting for age, sex, race, comorbidities, and other confounders, the presence of an SFA occlusion was associated with poorer 6-min walk performance (1,031 vs. 1,169 feet, p = 0.006), slower fast-paced walking velocity (1.15 vs. 1.22 m/s, p = 0.042), and lower SPPB score (9.07 vs. 9.75, p = 0.038) compared with the absence of an SFA occlusion. More numerous collateral vessels were associated with better 6-min walk performance (0 to 3 collaterals - 1,064 feet, 4 to 7 collaterals - 1,165 feet, ≥8 collaterals - 1,246 feet, p trend = 0.007), faster usual-paced walking speed (0 to 3 collaterals - 0.84 m/s, 4 to 7 collaterals - 0.88 m/s, ≥8 collaterals - 0.91 m/s, p trend = 0.029), and faster rapid-paced walking speed (0 to 3 collaterals - 1.17 m/s, 4 to 7 collaterals - 1.22 m/s, ≥8 collaterals - 1.29 m/s, p trend = 0.002), adjusting for age, sex, race, comorbidities, ABI, and other confounders. Conclusions: Among PAD participants, MRI-visualized occlusions in the proximal SFA are associated with poorer functional performance, whereas more numerous collaterals are associated with better functional performance. (Magnetic Resonance Imaging to Identify Characteristics of Plaque Build-Up in People With Peripheral Arterial Disease; NCT00520312)

AB - Objectives: We studied associations of magnetic resonance imaging (MRI)-measured superficial femoral artery (SFA) occlusions with functional performance, leg symptoms, and collateral vessel number in peripheral artery disease (PAD). We studied associations of collateral vessel number with functional performance in PAD. Background: Associations of MRI-detected SFA occlusion and collateral vessel number with functional performance among individuals with PAD have not been reported. Methods: A total of 457 participants with an ankle brachial index (ABI) <1.00 had MRI measurement of the proximal SFA with 12 consecutive 2.5-μm cross-sectional images. An occluded SFA was defined as an SFA in which at least 1 segment was occluded. A nonoccluded SFA was defined as absence of any occluded slices. Collateral vessels were visualized with magnetic resonance angiography. Lower extremity functional performance was measured with the 6-min walk, 4-m walking velocity at usual and fastest pace, and the Short Physical Performance Battery (SPPB) (0 to 12 scale, 12 = best). Results: Adjusting for age, sex, race, comorbidities, and other confounders, the presence of an SFA occlusion was associated with poorer 6-min walk performance (1,031 vs. 1,169 feet, p = 0.006), slower fast-paced walking velocity (1.15 vs. 1.22 m/s, p = 0.042), and lower SPPB score (9.07 vs. 9.75, p = 0.038) compared with the absence of an SFA occlusion. More numerous collateral vessels were associated with better 6-min walk performance (0 to 3 collaterals - 1,064 feet, 4 to 7 collaterals - 1,165 feet, ≥8 collaterals - 1,246 feet, p trend = 0.007), faster usual-paced walking speed (0 to 3 collaterals - 0.84 m/s, 4 to 7 collaterals - 0.88 m/s, ≥8 collaterals - 0.91 m/s, p trend = 0.029), and faster rapid-paced walking speed (0 to 3 collaterals - 1.17 m/s, 4 to 7 collaterals - 1.22 m/s, ≥8 collaterals - 1.29 m/s, p trend = 0.002), adjusting for age, sex, race, comorbidities, ABI, and other confounders. Conclusions: Among PAD participants, MRI-visualized occlusions in the proximal SFA are associated with poorer functional performance, whereas more numerous collaterals are associated with better functional performance. (Magnetic Resonance Imaging to Identify Characteristics of Plaque Build-Up in People With Peripheral Arterial Disease; NCT00520312)

KW - atherosclerotic plaque

KW - intermittent claudication

KW - peripheral arterial disease

KW - physical functioning

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