Pseudotumor cerebri pathophysiology

Brian E. McGeeney, Deborah I Friedman

Research output: Contribution to journalReview article

57 Scopus citations

Abstract

Pseudotumor cerebri syndrome (PTCS) is an uncommon disorder of raised intracranial pressure of unknown etiology. The signs and symptoms have been well described but the pathogenesis remains a mystery. Most of the evidence suggests increased resistance to cerebrospinal fluid outflow as being pivotal to the disorder. Any comprehensive theory on causation will have to explain the preponderance of obese women of childbearing age with primary PTCS and lack of ventriculomegaly in the disorder. It is possible that female sex hormones, along with endocrinologically active adipose tissue, directly result in the syndrome, in those genetically predisposed. Aldosterone has been proposed also as important in the development of PTCS. Vitamin A, in the form of retinoic acid, may also play a pivotal role, and is influenced by both estrogen and adipose tissue. This article reviews proposed mechanisms of PTCS.

Original languageEnglish (US)
Pages (from-to)445-458
Number of pages14
JournalHeadache
Volume54
Issue number3
DOIs
StatePublished - Mar 2014

Keywords

  • cerebral venous system
  • idiopathic intracranial hypertension
  • pathophysiology
  • pseudotumor cerebri
  • retinol

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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