Psychosis proneness and ADHD in young relatives of schizophrenia patients

Matcheri S. Keshavan, Mandayam Sujata, Akhil Mehra, Debra M. Montrose, John A. Sweeney

Research output: Contribution to journalArticle

75 Scopus citations


Symptoms resembling the attentional deficit hyperactivity disorder (ADHD) are frequently observed in young relatives at risk for schizophrenia (HR). We examined the frequency of the ADHD syndrome and its relationship to psychosis related psychopathology and neurobehavioral abnormalities in young HR subjects (n=29) and healthy comparison subjects (HC; n=30). Thirty-one percent of HR subjects (n=9) had ADHD as a lifetime Axis-I diagnosis (HR-A). Compared to healthy comparison subjects, the HR-A group had impaired neurological function. The HR-A group but not the HR subjects without ADHD had higher scores on the Chapman's magical ideation and perceptual aberration scales. Thus, ADHD-like features are more prevalent in the HR population than the one described in the general population and are associated with more frequent psychosis-like clinical features. Longitudinal studies can clarify whether an "ADHD subgroup" within HR subjects predict an increased risk for future emergence of schizophrenia.

Original languageEnglish (US)
Pages (from-to)85-92
Number of pages8
JournalSchizophrenia Research
Issue number1
StatePublished - Jan 1 2003


  • ADHD
  • HR subjects
  • Psychosis proneness
  • Young relatives

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Keshavan, M. S., Sujata, M., Mehra, A., Montrose, D. M., & Sweeney, J. A. (2003). Psychosis proneness and ADHD in young relatives of schizophrenia patients. Schizophrenia Research, 59(1), 85-92.