Psychosocial predictors of medication non-adherence in pediatric organ transplantation: A systematic review

Michael O. Killian, Donna L. Schuman, Gillian S. Mayersohn, Kelli Nicole Triplett

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Adherence to immunosuppressant medication is critical to health and quality-of-life outcomes for children who have received a solid organ transplant. Research on the psychological and social predictors of medication adherence is essential to the advancement of pretransplant assessments and transplant psychosocial services. Despite the importance of identifying risk factors, the literature remains limited regarding psychosocial predictors of non-adherence. A systematic search was conducted to identify studies of the psychosocial predictors of post-transplant medication non-adherence in pediatric solid organ transplantation. From 1363 studies identified in searches of empirical literature, a final sample consisted of 54 publications representing 49 unique studies. Findings regarding psychosocial predictors were inconsistent with non-adherence associated largely with adolescence, racial/ethnic minority status, and presence of mental health issues. Familial predictors of non-adherence problems included single-parent households, lower socioeconomic status, lower family cohesion, presence of family conflict, and poor family communication. Several studies reported an association between non-adherence and social pressures (eg, peer social interaction, wanting to feel normal) among adolescent transplant recipients. While significant methodological and substantive gaps remain in this body of knowledge, this review synthesizes current evidence for assessment for transplant clinicians and researchers.

Original languageEnglish (US)
Article numbere13188
JournalPediatric Transplantation
Volume22
Issue number4
DOIs
StatePublished - Jun 1 2018

Fingerprint

Medication Adherence
Organ Transplantation
Pediatrics
Transplants
Single Parent
Family Conflict
Immunosuppressive Agents
Interpersonal Relations
Social Class
Publications
Mental Health
Communication
Quality of Life
Research Personnel
Psychology
Health
Research

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Psychosocial predictors of medication non-adherence in pediatric organ transplantation : A systematic review. / Killian, Michael O.; Schuman, Donna L.; Mayersohn, Gillian S.; Triplett, Kelli Nicole.

In: Pediatric Transplantation, Vol. 22, No. 4, e13188, 01.06.2018.

Research output: Contribution to journalReview article

@article{a74370dab8754637a054e6a50973d8b1,
title = "Psychosocial predictors of medication non-adherence in pediatric organ transplantation: A systematic review",
abstract = "Adherence to immunosuppressant medication is critical to health and quality-of-life outcomes for children who have received a solid organ transplant. Research on the psychological and social predictors of medication adherence is essential to the advancement of pretransplant assessments and transplant psychosocial services. Despite the importance of identifying risk factors, the literature remains limited regarding psychosocial predictors of non-adherence. A systematic search was conducted to identify studies of the psychosocial predictors of post-transplant medication non-adherence in pediatric solid organ transplantation. From 1363 studies identified in searches of empirical literature, a final sample consisted of 54 publications representing 49 unique studies. Findings regarding psychosocial predictors were inconsistent with non-adherence associated largely with adolescence, racial/ethnic minority status, and presence of mental health issues. Familial predictors of non-adherence problems included single-parent households, lower socioeconomic status, lower family cohesion, presence of family conflict, and poor family communication. Several studies reported an association between non-adherence and social pressures (eg, peer social interaction, wanting to feel normal) among adolescent transplant recipients. While significant methodological and substantive gaps remain in this body of knowledge, this review synthesizes current evidence for assessment for transplant clinicians and researchers.",
author = "Killian, {Michael O.} and Schuman, {Donna L.} and Mayersohn, {Gillian S.} and Triplett, {Kelli Nicole}",
year = "2018",
month = "6",
day = "1",
doi = "10.1111/petr.13188",
language = "English (US)",
volume = "22",
journal = "Pediatric Transplantation",
issn = "1397-3142",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Psychosocial predictors of medication non-adherence in pediatric organ transplantation

T2 - A systematic review

AU - Killian, Michael O.

AU - Schuman, Donna L.

AU - Mayersohn, Gillian S.

AU - Triplett, Kelli Nicole

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Adherence to immunosuppressant medication is critical to health and quality-of-life outcomes for children who have received a solid organ transplant. Research on the psychological and social predictors of medication adherence is essential to the advancement of pretransplant assessments and transplant psychosocial services. Despite the importance of identifying risk factors, the literature remains limited regarding psychosocial predictors of non-adherence. A systematic search was conducted to identify studies of the psychosocial predictors of post-transplant medication non-adherence in pediatric solid organ transplantation. From 1363 studies identified in searches of empirical literature, a final sample consisted of 54 publications representing 49 unique studies. Findings regarding psychosocial predictors were inconsistent with non-adherence associated largely with adolescence, racial/ethnic minority status, and presence of mental health issues. Familial predictors of non-adherence problems included single-parent households, lower socioeconomic status, lower family cohesion, presence of family conflict, and poor family communication. Several studies reported an association between non-adherence and social pressures (eg, peer social interaction, wanting to feel normal) among adolescent transplant recipients. While significant methodological and substantive gaps remain in this body of knowledge, this review synthesizes current evidence for assessment for transplant clinicians and researchers.

AB - Adherence to immunosuppressant medication is critical to health and quality-of-life outcomes for children who have received a solid organ transplant. Research on the psychological and social predictors of medication adherence is essential to the advancement of pretransplant assessments and transplant psychosocial services. Despite the importance of identifying risk factors, the literature remains limited regarding psychosocial predictors of non-adherence. A systematic search was conducted to identify studies of the psychosocial predictors of post-transplant medication non-adherence in pediatric solid organ transplantation. From 1363 studies identified in searches of empirical literature, a final sample consisted of 54 publications representing 49 unique studies. Findings regarding psychosocial predictors were inconsistent with non-adherence associated largely with adolescence, racial/ethnic minority status, and presence of mental health issues. Familial predictors of non-adherence problems included single-parent households, lower socioeconomic status, lower family cohesion, presence of family conflict, and poor family communication. Several studies reported an association between non-adherence and social pressures (eg, peer social interaction, wanting to feel normal) among adolescent transplant recipients. While significant methodological and substantive gaps remain in this body of knowledge, this review synthesizes current evidence for assessment for transplant clinicians and researchers.

UR - http://www.scopus.com/inward/record.url?scp=85045220839&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045220839&partnerID=8YFLogxK

U2 - 10.1111/petr.13188

DO - 10.1111/petr.13188

M3 - Review article

C2 - 29637674

AN - SCOPUS:85045220839

VL - 22

JO - Pediatric Transplantation

JF - Pediatric Transplantation

SN - 1397-3142

IS - 4

M1 - e13188

ER -