Pulling a MAST1 on Cisplatin Resistance

Ankita B. Jaykumar, Aroon S. Karra, Melanie H. Cobb

Research output: Contribution to journalShort survey

Abstract

In this issue of Cancer Cell, Jin and colleagues use a kinome-wide screen to identify MAST1 as a cause of cisplatin resistance. They demonstrate that this kinase is a novel activator of MEK1 and the MAPK cascade and that it can harness pathway output to block cisplatin-induced cell death. In this issue of Cancer Cell, Jin and colleagues use a kinome-wide screen to identify MAST1 as a cause of cisplatin resistance. They demonstrate that this kinase is a novel activator of MEK1 and the MAPK cascade and that it can harness pathway output to block cisplatin-induced cell death.

Original languageEnglish (US)
Pages (from-to)183-185
Number of pages3
JournalCancer Cell
Volume34
Issue number2
DOIs
StatePublished - Aug 13 2018

Fingerprint

Cisplatin
Cell Death
Phosphotransferases
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Pulling a MAST1 on Cisplatin Resistance. / Jaykumar, Ankita B.; Karra, Aroon S.; Cobb, Melanie H.

In: Cancer Cell, Vol. 34, No. 2, 13.08.2018, p. 183-185.

Research output: Contribution to journalShort survey

Jaykumar, Ankita B. ; Karra, Aroon S. ; Cobb, Melanie H. / Pulling a MAST1 on Cisplatin Resistance. In: Cancer Cell. 2018 ; Vol. 34, No. 2. pp. 183-185.
@article{29b2b7f919054ba0a2fdc145fd4e66d4,
title = "Pulling a MAST1 on Cisplatin Resistance",
abstract = "In this issue of Cancer Cell, Jin and colleagues use a kinome-wide screen to identify MAST1 as a cause of cisplatin resistance. They demonstrate that this kinase is a novel activator of MEK1 and the MAPK cascade and that it can harness pathway output to block cisplatin-induced cell death. In this issue of Cancer Cell, Jin and colleagues use a kinome-wide screen to identify MAST1 as a cause of cisplatin resistance. They demonstrate that this kinase is a novel activator of MEK1 and the MAPK cascade and that it can harness pathway output to block cisplatin-induced cell death.",
author = "Jaykumar, {Ankita B.} and Karra, {Aroon S.} and Cobb, {Melanie H.}",
year = "2018",
month = "8",
day = "13",
doi = "10.1016/j.ccell.2018.07.010",
language = "English (US)",
volume = "34",
pages = "183--185",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "2",

}

TY - JOUR

T1 - Pulling a MAST1 on Cisplatin Resistance

AU - Jaykumar, Ankita B.

AU - Karra, Aroon S.

AU - Cobb, Melanie H.

PY - 2018/8/13

Y1 - 2018/8/13

N2 - In this issue of Cancer Cell, Jin and colleagues use a kinome-wide screen to identify MAST1 as a cause of cisplatin resistance. They demonstrate that this kinase is a novel activator of MEK1 and the MAPK cascade and that it can harness pathway output to block cisplatin-induced cell death. In this issue of Cancer Cell, Jin and colleagues use a kinome-wide screen to identify MAST1 as a cause of cisplatin resistance. They demonstrate that this kinase is a novel activator of MEK1 and the MAPK cascade and that it can harness pathway output to block cisplatin-induced cell death.

AB - In this issue of Cancer Cell, Jin and colleagues use a kinome-wide screen to identify MAST1 as a cause of cisplatin resistance. They demonstrate that this kinase is a novel activator of MEK1 and the MAPK cascade and that it can harness pathway output to block cisplatin-induced cell death. In this issue of Cancer Cell, Jin and colleagues use a kinome-wide screen to identify MAST1 as a cause of cisplatin resistance. They demonstrate that this kinase is a novel activator of MEK1 and the MAPK cascade and that it can harness pathway output to block cisplatin-induced cell death.

UR - http://www.scopus.com/inward/record.url?scp=85050922917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050922917&partnerID=8YFLogxK

U2 - 10.1016/j.ccell.2018.07.010

DO - 10.1016/j.ccell.2018.07.010

M3 - Short survey

VL - 34

SP - 183

EP - 185

JO - Cancer Cell

JF - Cancer Cell

SN - 1535-6108

IS - 2

ER -