Pulling a MAST1 on Cisplatin Resistance

Ankita B. Jaykumar, Aroon S. Karra, Melanie H. Cobb

Research output: Contribution to journalShort survey

2 Scopus citations

Abstract

In this issue of Cancer Cell, Jin and colleagues use a kinome-wide screen to identify MAST1 as a cause of cisplatin resistance. They demonstrate that this kinase is a novel activator of MEK1 and the MAPK cascade and that it can harness pathway output to block cisplatin-induced cell death. In this issue of Cancer Cell, Jin and colleagues use a kinome-wide screen to identify MAST1 as a cause of cisplatin resistance. They demonstrate that this kinase is a novel activator of MEK1 and the MAPK cascade and that it can harness pathway output to block cisplatin-induced cell death.

Original languageEnglish (US)
Pages (from-to)183-185
Number of pages3
JournalCancer Cell
Volume34
Issue number2
DOIs
StatePublished - Aug 13 2018

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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