Pulmonary emphysema: Current concepts of pathogenesis

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Abstract

Pulmonary emphysema is a major public health problem and is primarily a disease of smokers. The pathogenesis of emphysema in smokers is likely to be multifactorial and may involve protease-antiprotease imbalance, abnormal host response to injury, the inactivation of antiproteases by oxidants, and direct damage of lung tissue by pulmonary phagocytes. The data regarding current concepts of pathogenesis of emphysema in smokers are reviewed in this article.

Original languageEnglish (US)
Pages (from-to)125-138
Number of pages14
JournalAmerican Journal of the Medical Sciences
Volume293
Issue number2
StatePublished - Jan 1 1987

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ASJC Scopus subject areas

  • Medicine(all)

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