Pulmonary histopathology in cocaine abusers

Michael E. Bailey, Armando E. Fraire, S. Donald Greenberg, Jeffrey Barnard, Philip T. Cagle

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Lung histopathology was reviewed from 52 autopsies with positive toxicologic tests for cocaine from the medical examiners' offices in Dallas and Austin, TX. The median patient age was 34.7 years, and the male to female ratio was 2:1. Twelve individuals primarily used the drug intravenously and six primarily smoked it, but in most patients usage history was not known. The most frequent manner of death was accidental, consisting predominantly of cocaine overdoses. Other frequent manners of death included both natural causes and homicides. Subjects with chest trauma were excluded from the study. Twenty-three age-matched control cases with negative cocaine histories and toxicologic tests also were obtained from medical examiner autopsies. Histopathologic findings in the cocaine abuse group included acute hemorrhage, 58% (P = .05); chronic hemorrhage, 40% (P < .01); interstitial pneumonitis/fibrosis, 38% (P < 0.01); congestion, 88% (P < .01); and intra-alveolar edema, 77% (P < .01). These changes were remarkably consistent regardless of locale or method of use. Our findings demonstrate that pulmonary hemorrhage is more frequent than suggested by clinical hemoptysis and that chronic pulmonary diseases such as interstitial fibrosis may develop in long-term users.

Original languageEnglish (US)
Pages (from-to)203-207
Number of pages5
JournalHuman Pathology
Volume25
Issue number2
DOIs
StatePublished - 1994

Fingerprint

Cocaine
Coroners and Medical Examiners
Hemorrhage
Lung
Autopsy
Fibrosis
Cocaine-Related Disorders
Hemoptysis
Homicide
Interstitial Lung Diseases
Lung Diseases
Edema
Chronic Disease
Thorax
History
Wounds and Injuries
Pharmaceutical Preparations

Keywords

  • cocaine
  • hemorrhage
  • interstitial fibrosis
  • interstitial pneumonitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Bailey, M. E., Fraire, A. E., Donald Greenberg, S., Barnard, J., & Cagle, P. T. (1994). Pulmonary histopathology in cocaine abusers. Human Pathology, 25(2), 203-207. https://doi.org/10.1016/0046-8177(94)90279-8

Pulmonary histopathology in cocaine abusers. / Bailey, Michael E.; Fraire, Armando E.; Donald Greenberg, S.; Barnard, Jeffrey; Cagle, Philip T.

In: Human Pathology, Vol. 25, No. 2, 1994, p. 203-207.

Research output: Contribution to journalArticle

Bailey, ME, Fraire, AE, Donald Greenberg, S, Barnard, J & Cagle, PT 1994, 'Pulmonary histopathology in cocaine abusers', Human Pathology, vol. 25, no. 2, pp. 203-207. https://doi.org/10.1016/0046-8177(94)90279-8
Bailey ME, Fraire AE, Donald Greenberg S, Barnard J, Cagle PT. Pulmonary histopathology in cocaine abusers. Human Pathology. 1994;25(2):203-207. https://doi.org/10.1016/0046-8177(94)90279-8
Bailey, Michael E. ; Fraire, Armando E. ; Donald Greenberg, S. ; Barnard, Jeffrey ; Cagle, Philip T. / Pulmonary histopathology in cocaine abusers. In: Human Pathology. 1994 ; Vol. 25, No. 2. pp. 203-207.
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