Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia

Matthias T F Wolf, Eva Mildenberger, Thomas Lennert, Ioannis Anagnostopoulos, Christina Zinn, Karl Paul, Rolf Keitzer, Hans Versmold

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report the case of a 12-year-old boy, who developed Epstein-Barr virus (EBV) associated post-transplant lymphoproliferative disease (PTLD) 7 years after renal transplantation. He responded well to the reduced immunosuppressive therapy and treatment with ganciclovir. Two years later he developed severe pneumonia and hypogammaglobulinaemia related to EBV infection exacerbation. An X-ray film revealed persistent pneumonia in the right lung. Lung biopsy showed a large, diffuse EBV-associated B-cell lymphoma. This constellation suggested re-occurrence of the primary PTLD. Conclusion: We present a case of recurring Epstein-Barr virus-associated post-transplant lymphoproliferative disease with a remarkably late onset in addition to hypogammaglobulinaemia.

Original languageEnglish (US)
Pages (from-to)180-183
Number of pages4
JournalEuropean Journal of Pediatrics
Volume162
Issue number3
StatePublished - Mar 1 2003

Fingerprint

Agammaglobulinemia
Human Herpesvirus 4
Transplants
Lung
Pneumonia
X-Ray Film
Ganciclovir
Epstein-Barr Virus Infections
B-Cell Lymphoma
Immunosuppressive Agents
Kidney Transplantation
Biopsy
Therapeutics

Keywords

  • Epstein-Barr virus
  • Hypogammaglobulinaemia
  • Post-transplant lymphoproliferative disease
  • Renal transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Wolf, M. T. F., Mildenberger, E., Lennert, T., Anagnostopoulos, I., Zinn, C., Paul, K., ... Versmold, H. (2003). Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia. European Journal of Pediatrics, 162(3), 180-183.

Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia. / Wolf, Matthias T F; Mildenberger, Eva; Lennert, Thomas; Anagnostopoulos, Ioannis; Zinn, Christina; Paul, Karl; Keitzer, Rolf; Versmold, Hans.

In: European Journal of Pediatrics, Vol. 162, No. 3, 01.03.2003, p. 180-183.

Research output: Contribution to journalArticle

Wolf, MTF, Mildenberger, E, Lennert, T, Anagnostopoulos, I, Zinn, C, Paul, K, Keitzer, R & Versmold, H 2003, 'Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia', European Journal of Pediatrics, vol. 162, no. 3, pp. 180-183.
Wolf MTF, Mildenberger E, Lennert T, Anagnostopoulos I, Zinn C, Paul K et al. Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia. European Journal of Pediatrics. 2003 Mar 1;162(3):180-183.
Wolf, Matthias T F ; Mildenberger, Eva ; Lennert, Thomas ; Anagnostopoulos, Ioannis ; Zinn, Christina ; Paul, Karl ; Keitzer, Rolf ; Versmold, Hans. / Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia. In: European Journal of Pediatrics. 2003 ; Vol. 162, No. 3. pp. 180-183.
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