Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia

Matthias T F Wolf, Eva Mildenberger, Thomas Lennert, Ioannis Anagnostopoulos, Christina Zinn, Karl Paul, Rolf Keitzer, Hans Versmold

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We report the case of a 12-year-old boy, who developed Epstein-Barr virus (EBV) associated post-transplant lymphoproliferative disease (PTLD) 7 years after renal transplantation. He responded well to the reduced immunosuppressive therapy and treatment with ganciclovir. Two years later he developed severe pneumonia and hypogammaglobulinaemia related to EBV infection exacerbation. An X-ray film revealed persistent pneumonia in the right lung. Lung biopsy showed a large, diffuse EBV-associated B-cell lymphoma. This constellation suggested re-occurrence of the primary PTLD. Conclusion: We present a case of recurring Epstein-Barr virus-associated post-transplant lymphoproliferative disease with a remarkably late onset in addition to hypogammaglobulinaemia.

Original languageEnglish (US)
Pages (from-to)180-183
Number of pages4
JournalEuropean Journal of Pediatrics
Volume162
Issue number3
StatePublished - Mar 1 2003

Keywords

  • Epstein-Barr virus
  • Hypogammaglobulinaemia
  • Post-transplant lymphoproliferative disease
  • Renal transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Wolf, M. T. F., Mildenberger, E., Lennert, T., Anagnostopoulos, I., Zinn, C., Paul, K., Keitzer, R., & Versmold, H. (2003). Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia. European Journal of Pediatrics, 162(3), 180-183.