Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia

Matthias T F Wolf; Eva Mildenberger; Thomas Lennert; Ioannis Anagnostopoulos; Christina Zinn; Karl Paul; Rolf Keitzer; Hans Versmold

doi:10.1007/s00431-002-1120-8

Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia

Matthias T F Wolf, Eva Mildenberger, Thomas Lennert, Ioannis Anagnostopoulos, Christina Zinn, Karl Paul, Rolf Keitzer, Hans Versmold

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We report the case of a 12-year-old boy, who developed Epstein-Barr virus (EBV) associated post-transplant lymphoproliferative disease (PTLD) 7 years after renal transplantation. He responded well to the reduced immunosuppressive therapy and treatment with ganciclovir. Two years later he developed severe pneumonia and hypogammaglobulinaemia related to EBV infection exacerbation. An X-ray film revealed persistent pneumonia in the right lung. Lung biopsy showed a large, diffuse EBV-associated B-cell lymphoma. This constellation suggested re-occurrence of the primary PTLD. Conclusion: We present a case of recurring Epstein-Barr virus-associated post-transplant lymphoproliferative disease with a remarkably late onset in addition to hypogammaglobulinaemia.

Original language	English (US)
Pages (from-to)	180-183
Number of pages	4
Journal	European Journal of Pediatrics
Volume	162
Issue number	3
DOIs	https://doi.org/10.1007/s00431-002-1120-8
State	Published - Mar 1 2003

Keywords

Epstein-Barr virus
Hypogammaglobulinaemia
Post-transplant lymphoproliferative disease
Renal transplantation

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1007/s00431-002-1120-8

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title = "Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia",

abstract = "We report the case of a 12-year-old boy, who developed Epstein-Barr virus (EBV) associated post-transplant lymphoproliferative disease (PTLD) 7 years after renal transplantation. He responded well to the reduced immunosuppressive therapy and treatment with ganciclovir. Two years later he developed severe pneumonia and hypogammaglobulinaemia related to EBV infection exacerbation. An X-ray film revealed persistent pneumonia in the right lung. Lung biopsy showed a large, diffuse EBV-associated B-cell lymphoma. This constellation suggested re-occurrence of the primary PTLD. Conclusion: We present a case of recurring Epstein-Barr virus-associated post-transplant lymphoproliferative disease with a remarkably late onset in addition to hypogammaglobulinaemia.",

keywords = "Epstein-Barr virus, Hypogammaglobulinaemia, Post-transplant lymphoproliferative disease, Renal transplantation",

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AU - Wolf, Matthias T F

AU - Mildenberger, Eva

AU - Lennert, Thomas

AU - Anagnostopoulos, Ioannis

AU - Zinn, Christina

AU - Paul, Karl

AU - Keitzer, Rolf

AU - Versmold, Hans

PY - 2003/3/1

Y1 - 2003/3/1

N2 - We report the case of a 12-year-old boy, who developed Epstein-Barr virus (EBV) associated post-transplant lymphoproliferative disease (PTLD) 7 years after renal transplantation. He responded well to the reduced immunosuppressive therapy and treatment with ganciclovir. Two years later he developed severe pneumonia and hypogammaglobulinaemia related to EBV infection exacerbation. An X-ray film revealed persistent pneumonia in the right lung. Lung biopsy showed a large, diffuse EBV-associated B-cell lymphoma. This constellation suggested re-occurrence of the primary PTLD. Conclusion: We present a case of recurring Epstein-Barr virus-associated post-transplant lymphoproliferative disease with a remarkably late onset in addition to hypogammaglobulinaemia.

AB - We report the case of a 12-year-old boy, who developed Epstein-Barr virus (EBV) associated post-transplant lymphoproliferative disease (PTLD) 7 years after renal transplantation. He responded well to the reduced immunosuppressive therapy and treatment with ganciclovir. Two years later he developed severe pneumonia and hypogammaglobulinaemia related to EBV infection exacerbation. An X-ray film revealed persistent pneumonia in the right lung. Lung biopsy showed a large, diffuse EBV-associated B-cell lymphoma. This constellation suggested re-occurrence of the primary PTLD. Conclusion: We present a case of recurring Epstein-Barr virus-associated post-transplant lymphoproliferative disease with a remarkably late onset in addition to hypogammaglobulinaemia.

KW - Epstein-Barr virus

KW - Hypogammaglobulinaemia

KW - Post-transplant lymphoproliferative disease

KW - Renal transplantation

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Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia

Abstract

Keywords

ASJC Scopus subject areas

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