Pulmonary vascular disease in total anomalous pulmonary venous drainage

E. A. Newfeld, A. Wilson, M. H. Paul, J. S. Reisch

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Pulmonary vascular disease (PVD) was assessed by a qualitative and quantitative histopathologic analysis of lung specimens of 40 patients (age at autopsy 5 days to 12 years, median 3 months) with total anomalous pulmonary venous drainage. A PVD index was derived by counting the number of vessels with each Heath-Edwards grade of PVD (PVD index = [0 (N normal) +1(N grade 1) +2 (N grade 2).... +6 (N grade 6)]/number of vessels graded, where N = the number of patients) in randomly selected pulmonary resistance vessels 30-300 μ in diameter. Patients with pulmonary venous obstruction died earlier and had a higher PVD index as a group than patients with unobstructed venous drainage. A remarkable degree of advanced pulmonary vascular changes was found in the entire group, even young infants. Pulmonary vascular obstructive disease is an important factor in the pathophysiology of this lesion. Careful attention to the prevention and management of increased pulmonary vascular resistance in the postoperative period may improve survival.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalCirculation
Volume61
Issue number1
StatePublished - 1980

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Vascular Diseases
Lung Diseases
Drainage
Lung
Postoperative Period
Vascular Resistance
Blood Vessels
Autopsy
Survival

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Newfeld, E. A., Wilson, A., Paul, M. H., & Reisch, J. S. (1980). Pulmonary vascular disease in total anomalous pulmonary venous drainage. Circulation, 61(1), 103-109.

Pulmonary vascular disease in total anomalous pulmonary venous drainage. / Newfeld, E. A.; Wilson, A.; Paul, M. H.; Reisch, J. S.

In: Circulation, Vol. 61, No. 1, 1980, p. 103-109.

Research output: Contribution to journalArticle

Newfeld, EA, Wilson, A, Paul, MH & Reisch, JS 1980, 'Pulmonary vascular disease in total anomalous pulmonary venous drainage', Circulation, vol. 61, no. 1, pp. 103-109.
Newfeld, E. A. ; Wilson, A. ; Paul, M. H. ; Reisch, J. S. / Pulmonary vascular disease in total anomalous pulmonary venous drainage. In: Circulation. 1980 ; Vol. 61, No. 1. pp. 103-109.
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