Pulsatile administration of low-dose gonadotropin-releasing hormone. Ovulation and pregnancy in women with hypothalamic amenorrhea

D. S. Miller, R. R. Reid, N. S. Cetel, R. W. Rebar, S. S. Yen

Research output: Contribution to journalArticle


We administered pulsatile low doses of gonadotropin-releasing hormone (GnRH) (1 to 5 μg) to patients whose anovulation was caused by relative and absolute deficiency of endogenous GnRH. Eight such patients, including one with previous pituitary stalk transection, were treated during a total of 23 cycles; pulses of GnRH were administered via a portable pump every 96 or 120 minutes. Activation of pituitary-ovarian function with orderly development of a single dominant follicle, a luteinizing hormone surge, and ovulation occurred in 20 of the 23 cycles. The other three cycles were anovulatory. All patients responded, and five (62%) of the eight conceived, for a total of seven pregnancies and four full-term deliveries of normal infants. This study demonstrates that small pulsatile doses of GnRH can activate cyclic pituitary-ovarian function in hypogonadotropin-acyclic women and induce ovulation resulting in pregnancy and live birth.

Original languageEnglish (US)
Pages (from-to)2937-2941
Number of pages5
JournalJournal of the American Medical Association
Issue number21
StatePublished - 1983


ASJC Scopus subject areas

  • Medicine(all)

Cite this