Pulseless electrical activity and asystolic cardiac arrest in infants: identifying factors that influence outcomes

Kathryn Best; Myra H. Wyckoff; Rong Huang; Ethan Sandford; Noorjahan Ali

doi:10.1038/s41372-022-01349-x

Pulseless electrical activity and asystolic cardiac arrest in infants: identifying factors that influence outcomes

Kathryn Best, Myra H. Wyckoff, Rong Huang, Ethan Sandford, Noorjahan Ali

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: There is limited information on pulseless electrical activity (PEA)/asystolic cardiac arrest (CA) in the infant population. The aim is to describe the incidence and factors associated with outcomes in infants with PEA/asystolic CA. Methods: Single-center retrospective chart review study of infants less than one year of age who suffer in-hospital PEA/asystolic CA from January 1 2011 to June 30 2019. The primary outcome was the return of spontaneous circulation. The secondary outcome was survival to discharge. Results: CA occurred in 148 infants and PEA/asystolic was found in 38 (26%). Of those 29 (76%) achieved ROSC, and 12 (32%) survived to discharge. Infants on inotrope support or receiving longer duration of chest compressions and epinephrine had increase mortality. All infants with respiratory etiology of arrest survived to hospital discharge. Conclusion: PEA/asystolic CAs are uncommon. Poor prognostic indicators include the need for pre-arrest inotrope support and increased duration of chest compressions.

Original language	English (US)
Pages (from-to)	574-579
Number of pages	6
Journal	Journal of Perinatology
Volume	42
Issue number	5
DOIs	https://doi.org/10.1038/s41372-022-01349-x
State	Published - May 2022

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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title = "Pulseless electrical activity and asystolic cardiac arrest in infants: identifying factors that influence outcomes",

abstract = "Background: There is limited information on pulseless electrical activity (PEA)/asystolic cardiac arrest (CA) in the infant population. The aim is to describe the incidence and factors associated with outcomes in infants with PEA/asystolic CA. Methods: Single-center retrospective chart review study of infants less than one year of age who suffer in-hospital PEA/asystolic CA from January 1 2011 to June 30 2019. The primary outcome was the return of spontaneous circulation. The secondary outcome was survival to discharge. Results: CA occurred in 148 infants and PEA/asystolic was found in 38 (26%). Of those 29 (76%) achieved ROSC, and 12 (32%) survived to discharge. Infants on inotrope support or receiving longer duration of chest compressions and epinephrine had increase mortality. All infants with respiratory etiology of arrest survived to hospital discharge. Conclusion: PEA/asystolic CAs are uncommon. Poor prognostic indicators include the need for pre-arrest inotrope support and increased duration of chest compressions.",

author = "Kathryn Best and Wyckoff, {Myra H.} and Rong Huang and Ethan Sandford and Noorjahan Ali",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2022",

month = may,

doi = "10.1038/s41372-022-01349-x",

language = "English (US)",

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T1 - Pulseless electrical activity and asystolic cardiac arrest in infants

T2 - identifying factors that influence outcomes

AU - Best, Kathryn

AU - Wyckoff, Myra H.

AU - Huang, Rong

AU - Sandford, Ethan

AU - Ali, Noorjahan

PY - 2022/5

Y1 - 2022/5

N2 - Background: There is limited information on pulseless electrical activity (PEA)/asystolic cardiac arrest (CA) in the infant population. The aim is to describe the incidence and factors associated with outcomes in infants with PEA/asystolic CA. Methods: Single-center retrospective chart review study of infants less than one year of age who suffer in-hospital PEA/asystolic CA from January 1 2011 to June 30 2019. The primary outcome was the return of spontaneous circulation. The secondary outcome was survival to discharge. Results: CA occurred in 148 infants and PEA/asystolic was found in 38 (26%). Of those 29 (76%) achieved ROSC, and 12 (32%) survived to discharge. Infants on inotrope support or receiving longer duration of chest compressions and epinephrine had increase mortality. All infants with respiratory etiology of arrest survived to hospital discharge. Conclusion: PEA/asystolic CAs are uncommon. Poor prognostic indicators include the need for pre-arrest inotrope support and increased duration of chest compressions.

AB - Background: There is limited information on pulseless electrical activity (PEA)/asystolic cardiac arrest (CA) in the infant population. The aim is to describe the incidence and factors associated with outcomes in infants with PEA/asystolic CA. Methods: Single-center retrospective chart review study of infants less than one year of age who suffer in-hospital PEA/asystolic CA from January 1 2011 to June 30 2019. The primary outcome was the return of spontaneous circulation. The secondary outcome was survival to discharge. Results: CA occurred in 148 infants and PEA/asystolic was found in 38 (26%). Of those 29 (76%) achieved ROSC, and 12 (32%) survived to discharge. Infants on inotrope support or receiving longer duration of chest compressions and epinephrine had increase mortality. All infants with respiratory etiology of arrest survived to hospital discharge. Conclusion: PEA/asystolic CAs are uncommon. Poor prognostic indicators include the need for pre-arrest inotrope support and increased duration of chest compressions.

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Pulseless electrical activity and asystolic cardiac arrest in infants: identifying factors that influence outcomes

Abstract

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