PUPylation: something old, something new, something borrowed, something Glu

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations


Most eukaryotic proteins are degraded by the 26S proteasome as a consequence of their covalent modification with ubiquitin. Although the proteasome is found in some prokaryotes, ubiquitin is not, which indicates that substrates are targeted to prokaryotic proteasomes by a fundamentally different mechanism. A recent study has identified Pup (prokaryotic ubiquitin-like protein) as a mycobacterial protein that functions in a manner analogous to ubiquitin for proteasome-dependent proteolysis in prokaryotes.

Original languageEnglish (US)
Pages (from-to)155-158
Number of pages4
JournalTrends in biochemical sciences
Issue number4
StatePublished - Apr 2009

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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