Pursuit eye movements as an intermediate phenotype across psychotic disorders: Evidence from the B-SNIP study

Rebekka Lencer, Andreas Sprenger, James L. Reilly, Jennifer E. McDowell, Leah H. Rubin, Judith A. Badner, Matcheri S. Keshavan, Godfrey D. Pearlson, Carol A. Tamminga, Elliot S. Gershon, Brett A. Clementz, John A. Sweeney

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Smooth pursuit eye tracking deficits are a promising intermediate phenotype for schizophrenia and possibly for psychotic disorders more broadly. The Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium investigated the severity and familiality of different pursuit parameters across psychotic disorders. Probands with schizophrenia (N=265), schizoaffective disorder (N=178), psychotic bipolar disorder (N=231), their first-degree relatives (N=306, N=217, N=273, respectively) and healthy controls (N=305) performed pursuit tracking tasks designed to evaluate sensorimotor and cognitive/predictive aspects of pursuit. Probands from all diagnostic groups were impaired on all pursuit measures of interest compared to controls (p

Original languageEnglish (US)
Pages (from-to)326-333
Number of pages8
JournalSchizophrenia Research
Volume169
Issue number1-3
DOIs
StatePublished - Dec 1 2015

Keywords

  • Bipolar disorder
  • Familiality
  • Predictive pursuit eye movements
  • Schizoaffective disorder
  • Schizophrenia
  • Sensorimotor processing

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Lencer, R., Sprenger, A., Reilly, J. L., McDowell, J. E., Rubin, L. H., Badner, J. A., Keshavan, M. S., Pearlson, G. D., Tamminga, C. A., Gershon, E. S., Clementz, B. A., & Sweeney, J. A. (2015). Pursuit eye movements as an intermediate phenotype across psychotic disorders: Evidence from the B-SNIP study. Schizophrenia Research, 169(1-3), 326-333. https://doi.org/10.1016/j.schres.2015.09.032