Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma

Sergey Malchenko; Elisabeth A. Seftor; Yuri Nikolsky; Susan L. Hasegawa; Sean Kuo; Jeff W. Stevens; Stas Poyarkov; Tatiana Nikolskaya; Tamara Kucaba; Min Wang; Hakim Abdulkawy; Thomas Casavant; Jose Morcuende; Joseph Buckwalter; Raymond Hohl; Barry Deyoung; Kemp Kernstine; Maria De Fatima Bonaldo; Mary J C Hendrix; Marcelo B. Soares; Vera Maria F C Soares

doi:10.1155/2012/820254

Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma

Sergey Malchenko, Elisabeth A. Seftor, Yuri Nikolsky, Susan L. Hasegawa, Sean Kuo, Jeff W. Stevens, Stas Poyarkov, Tatiana Nikolskaya, Tamara Kucaba, Min Wang, Hakim Abdulkawy, Thomas Casavant, Jose Morcuende, Joseph Buckwalter, Raymond Hohl, Barry Deyoung, Kemp Kernstine, Maria De Fatima Bonaldo, Mary J C Hendrix, Marcelo B. SoaresVera Maria F C Soares

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90 of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of multifunctional genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.

Original language	English (US)
Article number	820254
Journal	Sarcoma
Volume	2012
DOIs	https://doi.org/10.1155/2012/820254
State	Published - 2012

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging

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Malchenko, S., Seftor, E. A., Nikolsky, Y., Hasegawa, S. L., Kuo, S., Stevens, J. W., Poyarkov, S., Nikolskaya, T., Kucaba, T., Wang, M., Abdulkawy, H., Casavant, T., Morcuende, J., Buckwalter, J., Hohl, R., Deyoung, B., Kernstine, K., Bonaldo, M. D. F., Hendrix, M. J. C., ... Soares, V. M. F. C. (2012). Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma. Sarcoma, 2012, Article 820254. https://doi.org/10.1155/2012/820254

Malchenko, S, Seftor, EA, Nikolsky, Y, Hasegawa, SL, Kuo, S, Stevens, JW, Poyarkov, S, Nikolskaya, T, Kucaba, T, Wang, M, Abdulkawy, H, Casavant, T, Morcuende, J, Buckwalter, J, Hohl, R, Deyoung, B, Kernstine, K, Bonaldo, MDF, Hendrix, MJC, Soares, MB & Soares, VMFC 2012, 'Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma', Sarcoma, vol. 2012, 820254. https://doi.org/10.1155/2012/820254

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title = "Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma",

abstract = "Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90 of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of multifunctional genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.",

author = "Sergey Malchenko and Seftor, {Elisabeth A.} and Yuri Nikolsky and Hasegawa, {Susan L.} and Sean Kuo and Stevens, {Jeff W.} and Stas Poyarkov and Tatiana Nikolskaya and Tamara Kucaba and Min Wang and Hakim Abdulkawy and Thomas Casavant and Jose Morcuende and Joseph Buckwalter and Raymond Hohl and Barry Deyoung and Kemp Kernstine and Bonaldo, {Maria De Fatima} and Hendrix, {Mary J C} and Soares, {Marcelo B.} and Soares, {Vera Maria F C}",

year = "2012",

doi = "10.1155/2012/820254",

language = "English (US)",

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AU - Malchenko, Sergey

AU - Seftor, Elisabeth A.

AU - Nikolsky, Yuri

AU - Hasegawa, Susan L.

AU - Kuo, Sean

AU - Stevens, Jeff W.

AU - Poyarkov, Stas

AU - Nikolskaya, Tatiana

AU - Kucaba, Tamara

AU - Wang, Min

AU - Abdulkawy, Hakim

AU - Casavant, Thomas

AU - Morcuende, Jose

AU - Buckwalter, Joseph

AU - Hohl, Raymond

AU - Deyoung, Barry

AU - Kernstine, Kemp

AU - Bonaldo, Maria De Fatima

AU - Hendrix, Mary J C

AU - Soares, Marcelo B.

AU - Soares, Vera Maria F C

PY - 2012

Y1 - 2012

N2 - Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90 of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of multifunctional genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.

AB - Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90 of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of multifunctional genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.

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VL - 2012

JO - Sarcoma

JF - Sarcoma

M1 - 820254

ER -

Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma

Abstract

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