Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma

Sergey Malchenko, Elisabeth A. Seftor, Yuri Nikolsky, Susan L. Hasegawa, Sean Kuo, Jeff W. Stevens, Stas Poyarkov, Tatiana Nikolskaya, Tamara Kucaba, Min Wang, Hakim Abdulkawy, Thomas Casavant, Jose Morcuende, Joseph Buckwalter, Raymond Hohl, Barry Deyoung, Kemp Kernstine, Maria De Fatima Bonaldo, Mary J C Hendrix, Marcelo B. SoaresVera Maria F C Soares

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Abstract

Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90 of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of multifunctional genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.

Original languageEnglish (US)
Article number820254
JournalSarcoma
Volume2012
DOIs
Publication statusPublished - 2012

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ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Malchenko, S., Seftor, E. A., Nikolsky, Y., Hasegawa, S. L., Kuo, S., Stevens, J. W., ... Soares, V. M. F. C. (2012). Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma. Sarcoma, 2012, [820254]. https://doi.org/10.1155/2012/820254