Pyogenic liver abscess

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

First described by Hippocrates, pyogenic liver abscess is an uncommon but important hepatic infection. The relative infrequency of abscess formation, despite the extensive exposure of the liver to bacteria from its dual blood supply, is related to the efficiency of the Kupffer cells in filtering bacteria. Over the past several decades with easily accessible imaging techniques enabling prompt diagnosis, potent antibiotics and effective drainage procedures, the mortality from pyogenic liver abscess has declined dramatically. In the first large published series of cases of pyogenic liver abscess in the United States, based on patients at Charity Hospital in New Orleans, there was an incidence of 8 cases per 100 000 admissions. There was a 2:1 male predominance with a mortality rate of 72%. Several studies published around 40 years later show significant demographic changes. In the initial report most patients were in their 3rd decade of life compared to the 5th to 6th decades in later series. Although the incidence of abscesses appears to be increasing by a factor of 2, the male predominance has disappeared and the mortality rate has fallen to approximately 12%. These differences probably reflect changes in the underlying factors causing the abscesses. Most of the earlier cases likely resulted from intra-abdominal infections such as diverticulitis or appendicitis. With better diagnostic imaging techniques, along with the availability of potent antibiotics, complications from abscess formation after intra-abdominal infections has diminished significantly.

Original languageEnglish (US)
Title of host publicationClinical Infectious Disease
PublisherCambridge University Press
Pages327-330
Number of pages4
ISBN (Electronic)9780511722240
ISBN (Print)9780521871129
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

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Pyogenic Liver Abscess
Abscess
Intraabdominal Infections
Mortality
Anti-Bacterial Agents
Bacteria
Charities
Diverticulitis
Kupffer Cells
Liver
Incidence
Appendicitis
Diagnostic Imaging
Drainage
Demography
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Herlong, H. F. (2010). Pyogenic liver abscess. In Clinical Infectious Disease (pp. 327-330). Cambridge University Press. https://doi.org/10.1017/CBO9780511722240.046

Pyogenic liver abscess. / Herlong, H. Franklin.

Clinical Infectious Disease. Cambridge University Press, 2010. p. 327-330.

Research output: Chapter in Book/Report/Conference proceedingChapter

Herlong, HF 2010, Pyogenic liver abscess. in Clinical Infectious Disease. Cambridge University Press, pp. 327-330. https://doi.org/10.1017/CBO9780511722240.046
Herlong HF. Pyogenic liver abscess. In Clinical Infectious Disease. Cambridge University Press. 2010. p. 327-330 https://doi.org/10.1017/CBO9780511722240.046
Herlong, H. Franklin. / Pyogenic liver abscess. Clinical Infectious Disease. Cambridge University Press, 2010. pp. 327-330
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