Pyridine group assisted addition of diazo-compounds to imines in the 3-CC reaction of 2-aminopyridines, aldehydes, and diazo-compounds

Anton V. Gulevich, Victoria Helan, Donald J. Wink, Vladimir Gevorgyan

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

A novel three-component coupling (3-CC) reaction of 2-aminoazines, aromatic aldehydes, and diazo-compounds producing polyfunctional β-amino-α- diazo-compounds has been developed. The reaction features an unprecedented heterocycle-assisted addition of a diazo-compound to an imine. The obtained diazoesters were efficiently converted into valuable heterocycles as well as β-amino acid derivatives.

Original languageEnglish (US)
Pages (from-to)956-959
Number of pages4
JournalOrganic Letters
Volume15
Issue number4
DOIs
StatePublished - Feb 15 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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