Q-TWiST analysis of lapatinib combined with capecitabine for the treatment of metastatic breast cancer

B. Sherrill, M. M. Amonkar, S. Stein, M. Walker, C. Geyer, D. Cameron

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The addition of lapatinib (Tykerb/Tyverb) to capecitabine (Xeloda) delays disease progression more effectively than capecitabine monotherapy in women with previously treated HER2+ metastatic breast cancer (MBC). The quality-adjusted time without symptoms of disease or toxicity of treatment (Q-TWiST) method was used to compare treatments. The area under survival curves was partitioned into health states: toxicity (TOX), time without symptoms of disease progression or toxicity (TWiST), and relapse period until death or end of follow-up (REL). Average times spent in each state, weighted by utility, were derived and comparisons of Q-TWiST between groups performed with varying combinations of the utility weights. Utility weights of 0.5 for both TOX and REL, that is, counting 2 days of TOX or REL as 1 day of TWiST, resulted in a 7-week difference in quality-adjusted survival favouring combination therapy (P=0.0013). The Q-TWiST difference is clinically meaningful and was statistically significant across an entire matrix of possible utility weights. Results were robust in sensitivity analyses. An analysis with utilities based on EQ-5D scores was consistent with the above findings. Combination therapy of lapatinib with capecitabine resulted in greater quality-adjusted survival than capecitabine monotherapy in trastuzumab-refractory MBC patients.

Original languageEnglish (US)
Pages (from-to)711-715
Number of pages5
JournalBritish journal of cancer
Volume99
Issue number5
DOIs
StatePublished - Sep 2 2008

Keywords

  • Breast cancer
  • Lapatinib
  • Q-TWiST
  • Quality-adjusted survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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