Qed-1 - a target for unrestricted killing by T cells

K. Fischer Lindahl, B. Hausmann

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Two prototype target determinants for unrestricted killing by T cells are defined: Qed-1a, detected on B 6.Tlaa targets by C3H/HeJ lymphocytes primed in vivo and restimulated in vitro by B 10.BR spleen cells; and Qed-1b, detected on C57BL/6J lymphocytes by B 10.BR anti-C3H/HeJ effector cells generated in the same manner. Other mouse strains can be typed for Qed-1 by the ability of their lymphocytes to inhibit one of these lytic reactions. Of 55 inbred strains, 52 expressed either Qed-1a or Qed-1b, which thus behaved as products of alleles of a single locus, Qed-1. The remaining three strains, all H-2r, did not compete against specific lysis of Qed-1a, but inhibited Qed-1b-specific lysis only in part; it is proposed that these strains carry a third allele or haplotype, Qed-1c. The Qed-1 locus was mapped distal to Qa-2. Qed-1b was found on both normal and mitogen-activated lymphocytes and did not appear confined to any lymphoid subpopulation. Cytotoxic responses, not restricted by H-2 and specific for antigens controlled by the Tla region, could be induced in several combinations of H-2-identical strains differing at Qed-1. Cells of some strains, like B 10.BR, NZB, and SWR, responded directly in culture, even without priming in vivo.

Original languageEnglish (US)
Pages (from-to)289-298
Number of pages10
JournalEuropean Journal of Immunology
Volume10
Issue number4
StatePublished - 1980

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Lymphocytes
T-Lymphocytes
Alleles
H-2 Antigens
Mitogens
Haplotypes
Spleen
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology

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Fischer Lindahl, K., & Hausmann, B. (1980). Qed-1 - a target for unrestricted killing by T cells. European Journal of Immunology, 10(4), 289-298.

Qed-1 - a target for unrestricted killing by T cells. / Fischer Lindahl, K.; Hausmann, B.

In: European Journal of Immunology, Vol. 10, No. 4, 1980, p. 289-298.

Research output: Contribution to journalArticle

Fischer Lindahl, K & Hausmann, B 1980, 'Qed-1 - a target for unrestricted killing by T cells', European Journal of Immunology, vol. 10, no. 4, pp. 289-298.
Fischer Lindahl, K. ; Hausmann, B. / Qed-1 - a target for unrestricted killing by T cells. In: European Journal of Immunology. 1980 ; Vol. 10, No. 4. pp. 289-298.
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