Abstract
Two prototype target determinants for unrestricted killing by T cells are defined: Qed-1a, detected on B 6.Tlaa targets by C3H/HeJ lymphocytes primed in vivo and restimulated in vitro by B 10.BR spleen cells; and Qed-1b, detected on C57BL/6J lymphocytes by B 10.BR anti-C3H/HeJ effector cells generated in the same manner. Other mouse strains can be typed for Qed-1 by the ability of their lymphocytes to inhibit one of these lytic reactions. Of 55 inbred strains, 52 expressed either Qed-1a or Qed-1b, which thus behaved as products of alleles of a single locus, Qed-1. The remaining three strains, all H-2r, did not compete against specific lysis of Qed-1a, but inhibited Qed-1b-specific lysis only in part; it is proposed that these strains carry a third allele or haplotype, Qed-1c. The Qed-1 locus was mapped distal to Qa-2. Qed-1b was found on both normal and mitogen-activated lymphocytes and did not appear confined to any lymphoid subpopulation. Cytotoxic responses, not restricted by H-2 and specific for antigens controlled by the Tla region, could be induced in several combinations of H-2-identical strains differing at Qed-1. Cells of some strains, like B 10.BR, NZB, and SWR, responded directly in culture, even without priming in vivo.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 289-298 |
| Number of pages | 10 |
| Journal | European Journal of Immunology |
| Volume | 10 |
| Issue number | 4 |
| State | Published - 1980 |
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Cite this
Qed-1 - a target for unrestricted killing by T cells. / Fischer Lindahl, K.; Hausmann, B.
In: European Journal of Immunology, Vol. 10, No. 4, 1980, p. 289-298.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Qed-1 - a target for unrestricted killing by T cells
AU - Fischer Lindahl, K.
AU - Hausmann, B.
PY - 1980
Y1 - 1980
N2 - Two prototype target determinants for unrestricted killing by T cells are defined: Qed-1a, detected on B 6.Tlaa targets by C3H/HeJ lymphocytes primed in vivo and restimulated in vitro by B 10.BR spleen cells; and Qed-1b, detected on C57BL/6J lymphocytes by B 10.BR anti-C3H/HeJ effector cells generated in the same manner. Other mouse strains can be typed for Qed-1 by the ability of their lymphocytes to inhibit one of these lytic reactions. Of 55 inbred strains, 52 expressed either Qed-1a or Qed-1b, which thus behaved as products of alleles of a single locus, Qed-1. The remaining three strains, all H-2r, did not compete against specific lysis of Qed-1a, but inhibited Qed-1b-specific lysis only in part; it is proposed that these strains carry a third allele or haplotype, Qed-1c. The Qed-1 locus was mapped distal to Qa-2. Qed-1b was found on both normal and mitogen-activated lymphocytes and did not appear confined to any lymphoid subpopulation. Cytotoxic responses, not restricted by H-2 and specific for antigens controlled by the Tla region, could be induced in several combinations of H-2-identical strains differing at Qed-1. Cells of some strains, like B 10.BR, NZB, and SWR, responded directly in culture, even without priming in vivo.
AB - Two prototype target determinants for unrestricted killing by T cells are defined: Qed-1a, detected on B 6.Tlaa targets by C3H/HeJ lymphocytes primed in vivo and restimulated in vitro by B 10.BR spleen cells; and Qed-1b, detected on C57BL/6J lymphocytes by B 10.BR anti-C3H/HeJ effector cells generated in the same manner. Other mouse strains can be typed for Qed-1 by the ability of their lymphocytes to inhibit one of these lytic reactions. Of 55 inbred strains, 52 expressed either Qed-1a or Qed-1b, which thus behaved as products of alleles of a single locus, Qed-1. The remaining three strains, all H-2r, did not compete against specific lysis of Qed-1a, but inhibited Qed-1b-specific lysis only in part; it is proposed that these strains carry a third allele or haplotype, Qed-1c. The Qed-1 locus was mapped distal to Qa-2. Qed-1b was found on both normal and mitogen-activated lymphocytes and did not appear confined to any lymphoid subpopulation. Cytotoxic responses, not restricted by H-2 and specific for antigens controlled by the Tla region, could be induced in several combinations of H-2-identical strains differing at Qed-1. Cells of some strains, like B 10.BR, NZB, and SWR, responded directly in culture, even without priming in vivo.
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M3 - Article
C2 - 6967411
AN - SCOPUS:0018829466
VL - 10
SP - 289
EP - 298
JO - European Journal of Immunology
JF - European Journal of Immunology
SN - 0014-2980
IS - 4
ER -